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Native Bovine Hydroxyapatite Powder, Demineralised Bone Matrix Powder, and Purified Bone Collagen Membranes are Efficient in Repair of Critical-Sized Rat Calvarial Defects

Authors :
Alexey Veremeev
Roman Nikolayevich Bolgarin
Vladimir Georgiyevich Nesterenko
Anton G. Kutikhin
Alexander Andreev-Andrievskiy
Source :
Materials, Volume 13, Issue 15, Materials, Vol 13, Iss 3393, p 3393 (2020)
Publication Year :
2020
Publisher :
Multidisciplinary Digital Publishing Institute, 2020.

Abstract

Here we evaluated the efficacy of bone repair using various native bovine biomaterials (refined hydroxyapatite (HA), demineralised bone matrix (DBM), and purified bone collagen (COLL)) as compared with commercially available bone mineral and bone autografts. We employed a conventional critical-sized (8 mm diameter) rat calvarial defect model (6-month-old male Sprague&ndash<br />Dawley rats, n = 72 in total). The artificial defect was repaired using HA, DBM, COLL, commercially available bone mineral powder, bone calvarial autograft, or remained unfilled (n = 12 animals per group). Rats were euthanised 4 or 12 weeks postimplantation (n = 6 per time point) with the subsequent examination to assess the extent, volume, area, and mineral density of the repaired tissue by means of microcomputed tomography and hematoxylin and eosin staining. Bovine HA and DBM powder exhibited excellent repair capability similar to the autografts and commercially available bone mineral powder while COLL showed higher bone repair rate. We suggest that HA and DBM powder obtained from bovine bone tissue can be equally applied for the repair of bone defects and demonstrate sufficient potential to be implemented into clinical studies.

Details

Language :
English
ISSN :
19961944
Database :
OpenAIRE
Journal :
Materials
Accession number :
edsair.doi.dedup.....bf51229cde06997f3ba9fd60722eef7c
Full Text :
https://doi.org/10.3390/ma13153393