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Aortic Root Diameter and Arterial Stiffness: Conjoint Relations to the Incidence of Cardiovascular Disease in the Framingham Heart Study
- Source :
- Hypertension
- Publication Year :
- 2021
-
Abstract
- Higher central pulse pressure is associated with higher carotid-femoral pulse wave velocity (CFPWV) and an increased risk of cardiovascular disease (CVD). A smaller aortic root diameter (AoR) is associated with higher central pulse pressure. We hypothesized that the combination of a smaller AoR and higher CFPWV is associated with increased CVD risk (relative to a larger AoR and lower CFPWV). We tested this hypothesis in the community-based Framingham Study (N=1970, mean age 60 years, 57% women). We created sex-specific longitudinal echocardiographic AoR trajectories over 2 decades, categorizing participants into smaller versus larger AoR groups. We cross-classified participants based on their AoR trajectory and CFPWV (dichotomized at the sex-specific median). We used Cox regression to relate the cross-classified groups to CVD incidence on follow-up (median 17 years): lower CFPWV, larger AoR (referent group; 6.4/1000 person-years); lower CFPWV, smaller AoR (6.9/1000 person-years); higher CFPWV, larger AoR (23.1/1000 person-years); and higher CFPWV, smaller AoR (21.9/1000 person-years). In sex-pooled analyses, groups with higher CFPWV were associated with a multivariable-adjusted 1.8-fold risk of CVD ( P P for sex×AoR-CFPWV group interaction 0.04). In men, the group with smaller AoR and higher CFPWV was associated with a 2.5- to 2.8-fold risk of CVD ( P
- Subjects :
- Male
medicine.medical_specialty
Aortic root
Blood Pressure
Disease
Pulse Wave Analysis
Article
Framingham Heart Study
Vascular Stiffness
Internal medicine
medicine.artery
Internal Medicine
medicine
Humans
Longitudinal Studies
Antihypertensive Agents
Aorta
Aged
business.industry
Incidence (epidemiology)
Incidence
Middle Aged
medicine.disease
United States
Blood pressure
Cardiovascular Diseases
Hypertension
Arterial stiffness
Cardiology
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15244563
- Volume :
- 78
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Hypertension (Dallas, Tex. : 1979)
- Accession number :
- edsair.doi.dedup.....bf51f7c70688c2c2f1eba2d95810311f