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FinTRIMs, fish virus-inducible proteins with E3 ubiquitin ligase activity
- Source :
- Developmental and Comparative Immunology, Developmental and Comparative Immunology, Elsevier, 2012, 36 (2), pp.433-441. ⟨10.1016/j.dci.2011.08.010⟩, Developmental and Comparative Immunology, 2012, 36 (2), pp.433-441. ⟨10.1016/j.dci.2011.08.010⟩, Developmental and Comparative Immunology, 36(2), 433-441, Developmental and Comparative Immunology 36 (2012) 2
- Publication Year :
- 2012
- Publisher :
- HAL CCSD, 2012.
-
Abstract
- Chantier qualité GA; International audience; TRIM proteins have recently emerged as novel players in antiviral defense. TRIM proteins contain a tri-partite motif, composed of a RING zinc finger, one or two B-boxes and a coiled-coil domain. Many members of this large protein family of E3 ubiquitin ligases catalyze the attachment of ubiquitin to a substrate protein, an activity dependent on the RING domain. We earlier made a full description of the TRIM gene family in zebrafish and pufferfish and identified three multigene TRIM subsets, a feature unique to fish. To determine their biological role, we further characterized members of the finTRIM subset. FinTRIM gene expression was studied during development and in multiple tissues in adult rainbow trout. Upregulation of a large number of finTRIM upon viral stimulation suggests they are involved in antiviral immunity. We also demonstrate that two finTRIM members display E3 ubiquitin ligase activity, indicating that finTRIMs could regulate antiviral signaling through ubiquitination.
- Subjects :
- family
0302 clinical medicine
Ubiquitin
Cluster Analysis
Cloning, Molecular
Zinc finger
Genetics
Regulation of gene expression
0303 health sciences
biology
trim
Reverse Transcriptase Polymerase Chain Reaction
Gene Expression Regulation, Developmental
Immunohistochemistry
rainbow trout
Ubiquitin ligase
Cell biology
antiviral immunity
030220 oncology & carcinogenesis
Oncorhynchus mykiss
[SDV.IMM]Life Sciences [q-bio]/Immunology
trim proteins
antiviral defense
e2 enzymes
fintrim
Fish Proteins
animal structures
Protein family
Ubiquitin-Protein Ligases
Immunology
Celbiologie en Immunologie
Real-Time Polymerase Chain Reaction
ubiquitination
Gene Expression Regulation, Enzymologic
Cell Line
Novirhabdovirus
03 medical and health sciences
deep sequencing
positive selection
expression
Gene family
Animals
polyubiquitin chains
030304 developmental biology
retroviral restriction
motif
Tripartite motif family
rainbow-trout
Cell Biology and Immunology
biology.protein
WIAS
RNA
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 0145305X
- Database :
- OpenAIRE
- Journal :
- Developmental and Comparative Immunology, Developmental and Comparative Immunology, Elsevier, 2012, 36 (2), pp.433-441. ⟨10.1016/j.dci.2011.08.010⟩, Developmental and Comparative Immunology, 2012, 36 (2), pp.433-441. ⟨10.1016/j.dci.2011.08.010⟩, Developmental and Comparative Immunology, 36(2), 433-441, Developmental and Comparative Immunology 36 (2012) 2
- Accession number :
- edsair.doi.dedup.....bfa11ab2eb738c556ed5a6350181c60d