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Strontium-doped organic-inorganic hybrids towards three-dimensional scaffolds for osteogenic cells
- Source :
- Materials Sciences and Engineering: C, Materials Sciences and Engineering: C, Elsevier, 2016, 68, pp.117-127. ⟨10.1016/j.msec.2016.05.105⟩, Materials Sciences and Engineering: C, 2016, 68, pp.117-127. ⟨10.1016/j.msec.2016.05.105⟩
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- International audience; Biomimetic organic–inorganic hybrid bioscaffolds are developed to complement or replace damaged fragments in bone tissue surgery. The aim of this work was to develop a simple and fast method to prepare composite material for bone engineering, avoiding time consuming and complex methodologies. The resulting materials (also called in this work as hybrid composites or hybrid scaffolds) have a three-dimensional macroporous polymer-like network derived from triethoxyvinylsilane (TEVS) and 2-hydroxyethylmethacrylate (HEMA) monomers, with incorporated calcium, strontium, and phosphate ions. The materials were fully characterized using FT-IR, biomineralization studies, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy, scratch tests, Young's modulus and compressive strength tests, and gas physisorption. We report a comprehensive study on the in vitro effect of novel strontium doped materials on human bone cells. In vitro investigations were conducted using a normal human osteoblast cell line that mimics the cellular events of the in vivo intramembranous bone formation process. The materials do not have a negative impact on the survival of the normal human osteoblasts; moreover, materials doped with strontium show that not only are cells able to survive, but they also attach to and grow on a bioscaffolds surface. For this reason, they may be used in future in vivo experiments.
- Subjects :
- Materials science
Scanning electron microscope
chemistry.chemical_element
Bioengineering
Nanotechnology
02 engineering and technology
010402 general chemistry
Methacrylate
Bone tissue
01 natural sciences
Biomaterials
Physisorption
Osteogenesis
In vivo
medicine
Humans
Organic–inorganic hybrids
Bone
[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials
Cells, Cultured
Scaffolds
Strontium
Osteoblasts
Tissue Scaffolds
[CHIM.MATE]Chemical Sciences/Material chemistry
Silanes
021001 nanoscience & nanotechnology
0104 chemical sciences
Compressive strength
medicine.anatomical_structure
chemistry
Mechanics of Materials
Methacrylates
Osteoporosis
0210 nano-technology
Biomineralization
Subjects
Details
- ISSN :
- 09284931
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Materials Science and Engineering: C
- Accession number :
- edsair.doi.dedup.....bfc63eee36f3a36db88ac974852ee78b