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Impact of glucose tolerance status on the development of coronary artery disease among working-age men
- Source :
- Diabetes & Metabolism. 43:261-264
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Aims To examine the impact of glucose tolerance status on the development of coronary artery disease (CAD) in working-age men in Japan. Methods This population-based retrospective cohort study included 111,621 men aged 31–60 years [63,558 with normal glucose tolerance (NGT); 37,126 with prediabetes; 10,937 with diabetes]. The Cox proportional-hazards regression model was used to identify variables related to the incidence of CAD. Results Multivariate analysis showed that, compared with NGT, diabetes increased the risk of CAD by 17.3 times (95% CI: 6.36–47.0) at ages 31–40 years, by 2.74 times (95% CI: 1.85–4.05) at ages 41–50 years and by 2.47 times (95% CI: 1.69–3.59) at ages 51–60 years. The HRs for CAD in men with diabetes aged 31–40 equaled that of men with NGT aged 51–60 [18.2 (7.15–46.4) and 19.4 (8.28–45.4), respectively]. Conclusion The impact of diabetes on CAD was markedly greater in men aged 31–40 years compared with those aged 41–60 years.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Multivariate analysis
Endocrinology, Diabetes and Metabolism
Population
030209 endocrinology & metabolism
Coronary Artery Disease
030204 cardiovascular system & hematology
Prediabetic State
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Endocrinology
Japan
Internal medicine
Diabetes mellitus
Glucose Intolerance
Internal Medicine
medicine
Humans
Prediabetes
education
Retrospective Studies
Normal glucose tolerance
education.field_of_study
business.industry
Incidence (epidemiology)
Retrospective cohort study
General Medicine
Glucose Tolerance Test
Middle Aged
medicine.disease
Diabetes Mellitus, Type 2
business
Subjects
Details
- ISSN :
- 12623636
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Diabetes & Metabolism
- Accession number :
- edsair.doi.dedup.....bfcaf2a12b8a44f8efc4782ce19d3ffa