Back to Search
Start Over
The Efficacy of Anti-inflammatory Agents in the Prevention of Atrial Fibrillation Recurrences
The Efficacy of Anti-inflammatory Agents in the Prevention of Atrial Fibrillation Recurrences
- Source :
- Current medicinal chemistry. 28(1)
- Publication Year :
- 2019
-
Abstract
- Several studies have indicated an association between inflammation and the recurrence of Atrial Fibrillation (AF), especially after ablation, which is a therapeutic option leading to local inflammation. On the other hand, each AF can lead to another AF, as a general rule. Thus, preventing recurrences of AF is extremely important for patient outcomes. In this paper, we attempted to review the effect of medicinal agents with anti-inflammatory properties on the prevention of AF recurrence. There are several randomized controlled trials (RCTs) and meta-analyses on the prevention of AF recurrence using agents with anti-inflammatory properties, which include steroids, colchicine, statins, and n-3 fatty acids (n-3 FA). Clinical trials evaluating the efficacy of anti-inflammatory drugs in preventing the recurrence of AF led to inconsistent results for corticosteroids, statins and n-3 FAs. These results may be related to the fact that inflammation is not the only factor responsible for triggering recurrences of AF. For example, the presence of structural, mechanical and electrical remodeling could potentially be the most important factors that trigger recurrences of AF but these factors have not been addressed in most of the reported studies. Therefore, future clinical trials are needed to compare the efficacy of anti-inflammatory drugs in AF patients with, or without other factors. For colchicine, a potent anti-inflammatory drug, there are limited studies. However, all the studies investigating colchicine in the context of AF were consistent and promising, especially when colchicine was used on a short-term basis following ablation in patients with paroxysmal AF. Therefore, colchicine could be a promising candidate for further clinical studies involving recurrent AF.
- Subjects :
- Drug
media_common.quotation_subject
Anti-Inflammatory Agents
Inflammation
Context (language use)
Bioinformatics
01 natural sciences
Biochemistry
law.invention
03 medical and health sciences
chemistry.chemical_compound
Randomized controlled trial
Meta-Analysis as Topic
law
Recurrence
Drug Discovery
Atrial Fibrillation
Fatty Acids, Omega-3
Medicine
Colchicine
Humans
0101 mathematics
030304 developmental biology
media_common
Randomized Controlled Trials as Topic
Pharmacology
0303 health sciences
biology
business.industry
Organic Chemistry
C-reactive protein
Atrial fibrillation
medicine.disease
010101 applied mathematics
Clinical trial
Treatment Outcome
chemistry
biology.protein
Molecular Medicine
Steroids
medicine.symptom
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Anti-Arrhythmia Agents
Subjects
Details
- ISSN :
- 1875533X
- Volume :
- 28
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Current medicinal chemistry
- Accession number :
- edsair.doi.dedup.....bfcf3d23d5bd4cbdafa7552d7d810156