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Clinical characteristics of diabetic ketoacidosis in users and non-users of SGLT2 inhibitors
- Source :
- Diabetes & Metabolism. 45:453-457
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Aim This study investigated the clinical characteristics of diabetic ketoacidosis (DKA) and compared the DKA characteristics between patients treated with and without SGLT2 inhibitors. Methods Data were collected from patients aged ≥ 18 years admitted for DKA at nine centres in Korea between September 2014 and April 2017. The electronic medical records of these subjects were retrospectively reviewed. Based on their history of medications taken before admission, subjects were classified as either users or non-users of SGLT2 inhibitors and their clinical characteristics of DKA were compared. Results During the study, the main subtype of DKA episodes (n = 523) was identified as type 2 diabetes (51%). Average hospitalization duration was 11 days, and average intensive care unit (ICU) time was 2.5 days. The in-hospital mortality rate was 3%, but no users of SGLT2 inhibitors died during DKA treatment. In patients taking SGLT2 inhibitors (n = 15), DKA manifested at 124 days, on average, after starting the inhibitors (range: 7–380 days). Also, SGLT2 inhibitors users had significantly lower plasma glucose levels (413 mg/dL) compared with non-users (554 mg/dL), and longer ICU stays (4 vs. 2 days; P = 0.019). Conclusion In this report of recent data on the clinical features of DKA in Korea, patients using SGLT2 inhibitors needed longer treatment in ICUs compared with non-users and had lower levels of blood glucose, whereas DKA associated with SGLT2 inhibitors was rare.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
endocrine system diseases
Diabetic ketoacidosis
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Type 2 diabetes
030204 cardiovascular system & hematology
Non users
Diabetic Ketoacidosis
law.invention
03 medical and health sciences
0302 clinical medicine
Endocrinology
law
Internal medicine
Diabetes Mellitus
Internal Medicine
medicine
Humans
Hypoglycemic Agents
In patient
Hospital Mortality
Sodium-Glucose Transporter 2 Inhibitors
Retrospective Studies
Plasma glucose
business.industry
Medical record
Mortality rate
nutritional and metabolic diseases
General Medicine
Middle Aged
medicine.disease
Intensive care unit
Treatment Outcome
Female
business
Subjects
Details
- ISSN :
- 12623636
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Diabetes & Metabolism
- Accession number :
- edsair.doi.dedup.....bfd1cb911b44c89d96aeca4e909b7213
- Full Text :
- https://doi.org/10.1016/j.diabet.2019.01.001