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The association between chronic spontaneous urticaria and HLA class I and class II antigen
- Source :
- Turkish Journal of Medical Sciences
- Publication Year :
- 2020
- Publisher :
- The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS, 2020.
-
Abstract
- Background/aim Chronic spontaneous urticaria (CSU) is a chronic disease with an unknown etiology. In human leukocyte antigen (HLA) system, the association of class I and class II antigens with autoimmune diseases has been identified and HLA antigens that have a tendency to or can prevent chronic urticaria have been studied. The aim of this study is to investigate the association between chronic spontaneous urticaria and HLA class I and class II antigens. Materials and methods A total of 80 subjects, 40 patients with CSU and 40 healthy individuals were enrolled in the study. DNA sample isolation from blood was primarily done by the real-time polymerase chain reaction (RT-PCR) technique for the first time. Using HLA SSP Typing Kit (ROSE Cat. No: 800118) PCR technique, HLA-A, B, C, DRB and DQB alleles from DNA samples were analyzed. Results The mean age was 36.80 ± 9.48 years and the duration of the disease was 4.26 ± 5.18 years. Among the HLA class I and class II antigens, HLA-A was detected significantly more often in the control group (P = 0.039). HLA-DRB1 was more often detected in the CSU group but no statistical difference (P > 0.05). Conclusion It can be considered that HLA-DRB1 may have a tendency to CSU, while HLA-A might prevent the disease.
- Subjects :
- Adult
Male
Human leukocyte antigen
Disease
030204 cardiovascular system & hematology
Article
law.invention
Young Adult
03 medical and health sciences
0302 clinical medicine
Antigen
law
Humans
Medicine
Chronic Urticaria
HLA antigens
Typing
Allele
Polymerase chain reaction
Chronic urticaria
0303 health sciences
030306 microbiology
business.industry
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
General Medicine
Middle Aged
Chronic spontaneous urticaria
Cross-Sectional Studies
Immunology
Etiology
Female
genetic
business
Subjects
Details
- ISSN :
- 13036165
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- TURKISH JOURNAL OF MEDICAL SCIENCES
- Accession number :
- edsair.doi.dedup.....bfd9b663a5882a3d1dd2cf9185d5b271