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Dynamic Range of the Peripapillary Retinal Vessel Density for Detecting Glaucomatous Visual Field Damage
- Source :
- Ophthalmology Glaucoma. 2:103-110
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Purpose To evaluate the dynamic range of peripapillary retinal vessel density (ppVD) for predicting the severity of visual field (VF) damage in comparison with that of circumpapillary retinal nerve fiber layer thickness (cpRNFLT) in primary open-angle glaucoma (POAG) patients and to determine the severity of VF damage below which progressive VF loss becomes undetectable based on either ppVD or cpRNFLT. Design Cross-sectional study. Participants One hundred thirty-three POAG patients having ppVD, cpRNFLT, and VF sensitivity (VFS) measurements evaluated using OCT angiography, spectral-domain OCT, and standard automated perimetry, respectively. Methods Correlations between ppVD and VFS (vessel–function) and between cpRNFLT and VFS (structure–function) were assessed using both linear and fractional polynomial (FP) models. Davies' test was used to determine the breakpoints for VFS below which progressive VF loss became undetectable based on ppVD or cpRNFLT. Main Outcome Measures Comparison of the vessel–function and structure–function correlations, and the VFS breakpoints in each correlation. Results Both ppVD and cpRNFLT exhibited significant linear correlations with VFS globally. In the temporal–superior, temporal, and temporal–inferior sectors, the correlations were explained better by the FP model than by the linear model for both ppVD (P ≤ 0.009) and cpRNFLT (P ≤ 0.008). The breakpoints for VFS in the vessel–function and structure–function correlations were –8.28 dB and –6.41 dB, respectively, in the temporal–superior sector, –11.83 dB and –8.42 dB, respectively, in the temporal sector, and –7.92 dB and –6.28 dB, respectively, in the temporal–inferior sector. Conclusions The sectoral ppVD exhibits curvilinear correlations with VFS and has significant breakpoints below which the VFS decline becomes undetectable. The VFS breakpoints were lower for ppVD than for cpRNFLT, indicating that the dynamic range of ppVD is potentially larger for detecting more advanced VF damage.
- Subjects :
- Male
medicine.medical_specialty
Fundus Oculi
Optic Disk
Nerve fiber layer
Glaucoma
01 natural sciences
Correlation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Ophthalmology
medicine
Humans
Prospective Studies
Fluorescein Angiography
0101 mathematics
Scotoma
Dioptre
business.industry
Dynamic range
010102 general mathematics
Retinal Vessels
Retinal
General Medicine
Middle Aged
medicine.disease
Visual field
Retinal vessel
Cross-Sectional Studies
medicine.anatomical_structure
chemistry
030221 ophthalmology & optometry
Female
Visual Fields
business
Glaucoma, Open-Angle
Tomography, Optical Coherence
Follow-Up Studies
Subjects
Details
- ISSN :
- 25894196
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Ophthalmology Glaucoma
- Accession number :
- edsair.doi.dedup.....bfecfe9a7a841c7c2e1a564e0c750b71