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Assessing the cost-effectiveness of different measles vaccination strategies for children in the Democratic Republic of Congo
- Source :
- Vaccine, vol 35, iss 45, Doshi, RH; Eckhoff, P; Cheng, A; Hoff, NA; Mukadi, P; Shidi, C; et al.(2017). Assessing the cost-effectiveness of different measles vaccination strategies for children in the Democratic Republic of Congo. VACCINE, 35(45), 6187-6194. doi: 10.1016/j.vaccine.2017.09.038. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9pz520sz
- Publication Year :
- 2017
- Publisher :
- eScholarship, University of California, 2017.
-
Abstract
- IntroductionOne of the goals of the Global Measles and Rubella Strategic Plan is the reduction in global measles mortality, with high measles vaccination coverage as one of its core components. While measles mortality has been reduced more than 79%, the disease remains a major cause of childhood vaccine preventable disease burden globally. Measles immunization requires a two-dose schedule and only countries with strong, stable immunization programs can rely on routine services to deliver the second dose. In the Democratic Republic of Congo (DRC), weak health infrastructure and lack of provision of the second dose of measles vaccine necessitates the use of supplementary immunization activities (SIAs) to administer the second dose.MethodsWe modeled three vaccination strategies using an age-structured SIR (Susceptible-Infectious-Recovered) model to simulate natural measles dynamics along with the effect of immunization. We compared the cost-effectiveness of two different strategies for the second dose of Measles Containing Vaccine (MCV) to one dose of MCV through routine immunization services over a 15-year time period for a hypothetical birth cohort of 3 million children.ResultsCompared to strategy 1 (MCV1 only), strategy 2 (MCV2 by SIA) would prevent a total of 5,808,750 measles cases, 156,836 measles-related deaths and save U.S. $199 million. Compared to strategy 1, strategy 3 (MCV2 by RI) would prevent a total of 13,232,250 measles cases, 166,475 measles-related deaths and save U.S. $408 million.DiscussionVaccination recommendations should be tailored to each country, offering a framework where countries can adapt to local epidemiological and economical circumstances in the context of other health priorities. Our results reflect the synergistic effect of two doses of MCV and demonstrate that the most cost-effective approach to measles vaccination in DRC is to incorporate the second dose of MCV in the RI schedule provided that high enough coverage can be achieved.
- Subjects :
- and promotion of well-being
Cost effectiveness
Cost-Benefit Analysis
Medical and Health Sciences
0302 clinical medicine
030212 general & internal medicine
Child
Pediatric
Vaccination
Biological Sciences
Infectious Diseases
3.4 Vaccines
Child, Preschool
Democratic Republic of the Congo
Molecular Medicine
Vaccine-preventable diseases
Infection
Adolescent
030231 tropical medicine
Measles Vaccine
Rubella
Measles
Vaccine Related
03 medical and health sciences
Environmental health
Virology
medicine
Humans
Preschool
Disease burden
Immunization Schedule
General Veterinary
General Immunology and Microbiology
Agricultural and Veterinary Sciences
business.industry
Immunization Programs
Prevention
Infant, Newborn
Public Health, Environmental and Occupational Health
Infant
medicine.disease
Newborn
Democratic Republic of Congo
Prevention of disease and conditions
Good Health and Well Being
Immunization
Immunology
Cost-effectiveness
Measles vaccine
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Vaccine, vol 35, iss 45, Doshi, RH; Eckhoff, P; Cheng, A; Hoff, NA; Mukadi, P; Shidi, C; et al.(2017). Assessing the cost-effectiveness of different measles vaccination strategies for children in the Democratic Republic of Congo. VACCINE, 35(45), 6187-6194. doi: 10.1016/j.vaccine.2017.09.038. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9pz520sz
- Accession number :
- edsair.doi.dedup.....bff8b8af3ec332aaff8e1073df031478