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A feto-placental co-culture model shows the complex disruptive effect of the antidepressant fluoxetine and its metabolite norfluoxetine on estrogen biosynthesis and serotonin transport

Authors :
J. Thomas Sanderson
Cathy Vaillancourt
Laetitia Laurent
Andrée-Anne Hudon Thibeault
Institut Armand Frappier (INRS-IAF)
Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP)
BioMed Research Centre [Montréal]
Institut National de la Recherche Scientifique [Québec] (INRS)-Université du Québec à Trois-Rivières (UQTR)-Université du Québec à Montréal = University of Québec in Montréal (UQAM)
Source :
Placenta, Placenta, Elsevier, 2015, 36 (9), pp.A37. ⟨10.1016/j.placenta.2015.07.297⟩
Publication Year :
2015
Publisher :
Elsevier BV, 2015.

Abstract

International audience; Up to 6.2% of pregnant women undergo antidepressant treatment with selective serotonin-reuptake inhibitors (SSRIs). SSRIs, which act on the serotonin transporter (SERT), have been associated with adverse effects on pregnancy. However, the action of one of the most prescribed SSRIs, fluoxetine, on the endocrine function of the feto-placental unit and placental serotonin transport has never been studied. Using a co-culture of BeWo (human trophoblast-like) and H295R (human fetal-like adrenocortical) cells, we studied the effects of fluoxetine and its active metabolite norfluoxetine on feto-placental estrogen biosynthesis and serotonin transport.

Details

ISSN :
01434004
Volume :
36
Database :
OpenAIRE
Journal :
Placenta
Accession number :
edsair.doi.dedup.....bffdd804ea0c752dd831904689228ef3
Full Text :
https://doi.org/10.1016/j.placenta.2015.07.297