Back to Search
Start Over
Clinical Trial of a Cancer Vaccine Targeting VEGF and KIF20A in Advanced Biliary Tract Cancer
- Source :
- Anticancer Research. 41:1485-1496
- Publication Year :
- 2021
- Publisher :
- Anticancer Research USA Inc., 2021.
-
Abstract
- Background As the prognosis of biliary tract cancer (BTC) is extremely poor and treatment options are limited, new treatment modalities are urgently needed. We designed a phase II clinical trial to investigate the immune responses and clinical benefits of OCV-C01, an HLA-A*24:02-restricted three-peptide cancer vaccine targeting VEGFR1, VEGFR2, and KIF20A. Patients and methods Participants were patients with advanced BTC who had unresectable tumours and were refractory to standard chemotherapy. OCV-C01 was injected weekly until the discontinuance criteria were met. Results Six participants, including four patients positive for HLA-A*24:02, were enrolled in this study for assessment of efficacy. Four out of six patients exhibited vaccine-specific T-cell responses to one or more of three antigens. Log-rank tests revealed that vaccine-specific T cell responses contributed significantly to overall survival. Conclusion The cancer vaccine had positive effects on survival, indicating that this approach warrants further clinical studies.
- Subjects :
- Male
Vascular Endothelial Growth Factor A
Oncology
Cancer Research
medicine.medical_specialty
Fever
medicine.medical_treatment
T cell
Kinesins
Translational research
Cancer Vaccines
Disease-Free Survival
Immune system
Antigen
Refractory
Internal medicine
medicine
Humans
Molecular Targeted Therapy
Aged
Aged, 80 and over
Chemotherapy
business.industry
Headache
General Medicine
Middle Aged
Prognosis
Vascular Endothelial Growth Factor Receptor-2
Clinical trial
Biliary Tract Neoplasms
medicine.anatomical_structure
Vaccines, Subunit
Female
Cancer vaccine
business
T-Lymphocytes, Cytotoxic
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....c029f52c551d4b70204147cfdb0e5543