Back to Search
Start Over
Concurrent radiotherapy and weekly chemotherapy of 5-fluorouracil and platinum agents for postoperative locoregional recurrence of oesophageal squamous cell carcinoma
- Source :
- Scientific Reports
- Publication Year :
- 2015
- Publisher :
- Nature Publishing Group, 2015.
-
Abstract
- The most optimal management for postoperative locoregional recurrence of oesophageal squamous cell carcinoma is still controversial. Several studies have reported the feasibility and efficacy of concurrent chemoradiotherapy (CCRT), mostly with three-weekly or four-weekly schedule of chemotherapy. However, treatment compliance was not quite satisfactory, probably due to treatment-related toxicities. Since CCRT with weekly chemotherapy regimens have demonstrated a favorable toxicity profile as well as promising survival in certain types of cancer, we aimed to evaluate the efficacy and toxicity of radiotherapy concurrently with weekly chemotherapy with 5-fluorouracil (5-FU) and platinum agents for patients with postoperative locoregional recurrence of oesophageal squamous cell carcinoma in our center. Twenty-seven consecutive patients who were diagnosed with postoperative locoregional recurrence of oesophageal squamous cell carcinoma and received CCRT with weekly chemotherapy of 5-FU and platinum agents were retrospectively analyzed. Our data showed that the present protocol of radiotherapy combined concurrently with weekly chemotherapy of 5-FU and platinum agents was a safe and effective salvage treatment for postoperative locoregional recurrence of oesophageal squamous cell carcinoma.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Esophageal Neoplasms
Organoplatinum Compounds
medicine.medical_treatment
Antineoplastic Agents
Article
Drug Administration Schedule
Internal medicine
medicine
Humans
Basal cell
Aged
Retrospective Studies
Weekly chemotherapy
Chemotherapy
Multidisciplinary
Platinum Agents
business.industry
Cancer
Chemoradiotherapy
Middle Aged
medicine.disease
Hematologic Diseases
Optimal management
Survival Rate
Radiation therapy
Treatment Outcome
Fluorouracil
Positron-Emission Tomography
Carcinoma, Squamous Cell
Female
Esophageal Squamous Cell Carcinoma
Neoplasm Recurrence, Local
Tomography, X-Ray Computed
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....c038a21cd6e76160526adf573ed7c66e
- Full Text :
- https://doi.org/10.1038/srep08071