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Herb-drug interaction: A case study of effects and involved mechanisms of cisplatin on the pharmacokinetics of ginsenoside Rb1 in tumor-bearing mice
- Source :
- Biomedicine & Pharmacotherapy, Vol 110, Iss, Pp 95-104 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Ginseng is often prescribed together with cisplatin for treatment of cancer, but the interaction between ginseng and cisplatin is still unknown. This study employed ginsenoside Rb1 (Rb1), one of the major components in ginseng, to explore the effects and involved mechanisms of cisplatin on the pharmacokinetics of ginseng. The effects of cisplatin on the pharmacokinetics of Rb1 and its bioactive metabolites Rd, Rg3, and F2 were investigated by using A549-bearing mice with and without cisplatin intervention. Our data showed that cisplatin could significantly decrease the AUC(0-t) and Cmax of Rd, Rg3, and F2, except Rb1. To evaluate the involved mechanisms, feces and intestinal mucosa were collected to explore the effects of cisplatin on the gut metabolism of Rb1 in vitro; meanwhile, Caco-2 cell model and small intestine histological characters were examined to evaluate the effects of cisplatin on the gut absorptive areas and permeability. The mechanisms involved may be mainly related to the comprehensive contributions of inhibited intestinal bacteria and mucosa metabolisms, narrowed intestinal absorptive area, increased efflux ratio of intestinal absorption and enhanced intestinal permeability. All these findings suggested that the dosage of ginseng traditionally used for health protection should be adjusted when it was prescribed together with cisplatin in the treatment of cancer.
- Subjects :
- 0301 basic medicine
Male
Ginsenosides
Ginsenoside Rb1
Interactions
Cmax
Herb-Drug Interactions
Mice, Nude
Antineoplastic Agents
RM1-950
Pharmacology
Intestinal absorption
03 medical and health sciences
Ginseng
Mice
Random Allocation
0302 clinical medicine
Intestinal mucosa
Pharmacokinetics
Medicine
Animals
Humans
Cisplatin
Mice, Inbred BALB C
Intestinal permeability
business.industry
General Medicine
medicine.disease
Xenograft Model Antitumor Assays
Small intestine
030104 developmental biology
medicine.anatomical_structure
Intestinal Absorption
A549 Cells
030220 oncology & carcinogenesis
Therapeutics. Pharmacology
Caco-2 Cells
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 07533322
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Biomedicine & Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....c040cae55f100a5ef85808b38c25f826