Back to Search
Start Over
The nucleus acts as a ruler tailoring cell responses to spatial constraints
- Source :
- Science, Science, American Association for the Advancement of Science, 2020, 370 (6514), pp.eaba2894. ⟨10.1126/science.aba2894⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- The microscopic environment inside a metazoan organism is highly crowded. Whether individual cells can tailor their behavior to the limited space remains unclear. In this study, we found that cells measure the degree of spatial confinement by using their largest and stiffest organelle, the nucleus. Cell confinement below a resting nucleus size deforms the nucleus, which expands and stretches its envelope. This activates signaling to the actomyosin cortex via nuclear envelope stretch-sensitive proteins, up-regulating cell contractility. We established that the tailored contractile response constitutes a nuclear ruler–based signaling pathway involved in migratory cell behaviors. Cells rely on the nuclear ruler to modulate the motive force that enables their passage through restrictive pores in complex three-dimensional environments, a process relevant to cancer cell invasion, immune responses, and embryonic development.
- Subjects :
- Cell Nucleus
0303 health sciences
Cytoplasm
Multidisciplinary
Chemistry
[SDV]Life Sciences [q-bio]
Cell
Proprioception
Article
Cortex (botany)
Cell biology
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Cell Movement
Cell Line, Tumor
Organelle
Cancer cell
medicine
Mechanotransduction
Signal transduction
Process (anatomy)
Nucleus
030217 neurology & neurosurgery
030304 developmental biology
Subjects
Details
- Language :
- English
- ISSN :
- 00368075 and 10959203
- Database :
- OpenAIRE
- Journal :
- Science, Science, American Association for the Advancement of Science, 2020, 370 (6514), pp.eaba2894. ⟨10.1126/science.aba2894⟩
- Accession number :
- edsair.doi.dedup.....c048ba48a7465eb928bdfa9c7e74e50a