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High frequency of endothelial colony forming cells marks a non-active myeloproliferative neoplasm with high risk of splanchnic vein thrombosis
- Source :
- PLoS ONE, Vol 5, Iss 12, p e15277 (2010), PLoS ONE
- Publication Year :
- 2010
- Publisher :
- Public Library of Science (PLoS), 2010.
-
Abstract
- Increased mobilization of circulating endothelial progenitor cells may represent a new biological hallmark of myeloproliferative neoplasms. We measured circulating endothelial colony forming cells (ECFCs) in 106 patients with primary myelofibrosis, fibrotic stage, 49 with prefibrotic myelofibrosis, 59 with essential thrombocythemia or polycythemia vera, and 43 normal controls. Levels of ECFC frequency for patient's characteristics were estimated by using logistic regression in univariate and multivariate setting. The sensitivity, specificity, likelihood ratios, and positive predictive value of increased ECFC frequency were calculated for the significantly associated characteristics. Increased frequency of ECFCs resulted independently associated with history of splanchnic vein thrombosis (adjusted odds ratio = 6.61, 95% CI = 2.54-17.16), and a summary measure of non-active disease, i.e. hemoglobin of 13.8 g/dL or lower, white blood cells count of 7.8×10(9)/L or lower, and platelet count of 400×10(9)/L or lower (adjusted odds ratio = 4.43, 95% CI = 1.45-13.49) Thirteen patients with splanchnic vein thrombosis non associated with myeloproliferative neoplasms were recruited as controls. We excluded a causal role of splanchnic vein thrombosis in ECFCs increase, since no control had elevated ECFCs. We concluded that increased frequency of ECFCs represents the biological hallmark of a non-active myeloproliferative neoplasm with high risk of splanchnic vein thrombosis. The recognition of this disease category copes with the phenotypic mimicry of myeloproliferative neoplasms. Due to inherent performance limitations of ECFCs assay, there is an urgent need to arrive to an acceptable standardization of ECFC assessment.
- Subjects :
- Male
Pathology
myeloproliferative neoplasm
Gastroenterology
Cohort Studies
Hematologic Cancers and Related Disorders
splanchnic vein thrombosis
Hemoglobins
Polycythemia vera
Molecular Cell Biology
Odds Ratio
Splanchnic Circulation
Polycythemia Vera
Aged, 80 and over
Venous Thrombosis
Thrombocytosis
Likelihood Functions
Multidisciplinary
Hematology
Middle Aged
Venous thrombosis
Oncology
Medicine
Female
Cellular Types
Research Article
Adult
medicine.medical_specialty
Clinical Pathology
Science
Sensitivity and Specificity
Myeloproliferative Disorders
Diagnostic Medicine
Internal medicine
medicine
Humans
Myelofibrosis
Biology
Myeloproliferative neoplasm
Aged
Essential thrombocythemia
business.industry
Endothelial Cells
Cancers and Neoplasms
Odds ratio
medicine.disease
Thrombocytopenia
Cross-Sectional Studies
Splanchnic vein thrombosis
business
Biomarkers
General Pathology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 5
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....c0592e60ac27a677c654dbebd5d2ade7