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Over-expression of both VEGF-C and Twist predicts poor prognosis in human breast cancer
- Source :
- Clinical & translational oncology, 21(9), 1250-1259. SPRINGER-VERLAG ITALIA SRL
- Publication Year :
- 2019
- Publisher :
- SPRINGER-VERLAG ITALIA SRL, 2019.
-
Abstract
- BackgroundAngiogenesis is an indispensable step in the growth and invasiveness of breast cancers involving a series of exquisite molecular steps. Pro-angiogenic factors, including vascular endothelial growth factor (VEGF), have been recognized as pivotal therapeutic targets in the treatment of breast cancer. More recently, a highly conserved transcription factor Twist has been reported to be involved in tumor angiogenesis and metastasis.MethodsThe expression of VEGF-C and Twist was immunohistochemically determined in tissue samples of primary tumors from 408 patients undergoing curative surgical resection for breast cancer. The correlations of VEGF-C and Twist expressions with clinicopathologic parameters as well as survival outcomes were evaluated.ResultsOf the 408 patients evaluated, approximately 70% had high expression of VEGF-C which was significantly associated with advanced tumor stages (P=0.019). Similarly, VEGF-C expression was associated with the proliferation index Ki67, N3 lymph node metastasis, and D2-40-positive lymphatic vessel invasion (LVI) in a univariate analysis. Furthermore, patients with high expressions of VEGF-C and Twist (V+T+) had significantly increased lymph node metastasis, higher clinical stage, and worse disease-free survival, DFS (P=0.001) and overall survival, OS (P=0.011).ConclusionsOur results suggested that co-expression of VEGF-C and Twist was associated with larger tumor size, higher numbers of lymph node involvement, D2-40-positive LVI, higher risk of distant metastasis, and worse DFS or OS in breast cancer patients.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Proliferation index
Angiogenesis
Vascular Endothelial Growth Factor C
VEGF-C
Breast Neoplasms
UP-REGULATION
Metastasis
TUMOR ANGIOGENESIS
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Breast cancer
Internal medicine
Lymphatic vessel
medicine
Biomarkers, Tumor
Humans
Twist
RECURRENCE
Lymph node
business.industry
Carcinoma, Ductal, Breast
Twist-Related Protein 1
LYMPH-NODE METASTASIS
Cancer
Nuclear Proteins
General Medicine
Middle Aged
medicine.disease
Prognosis
Lymphatic vessel invasion
Vascular endothelial growth factor
Gene Expression Regulation, Neoplastic
Survival Rate
030104 developmental biology
medicine.anatomical_structure
chemistry
030220 oncology & carcinogenesis
ENDOTHELIAL GROWTH-FACTOR
Female
business
Follow-Up Studies
LYMPHANGIOGENESIS
Subjects
Details
- Language :
- English
- ISSN :
- 1699048X
- Volume :
- 21
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Clinical & translational oncology
- Accession number :
- edsair.doi.dedup.....c05e468470bb6f5415eaae5347d2e9b3