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Overview of MicroRNAs in Cardiac Hypertrophy, Fibrosis, and Apoptosis
Overview of MicroRNAs in Cardiac Hypertrophy, Fibrosis, and Apoptosis
- Source :
- International Journal of Molecular Sciences, Vol 17, Iss 5, p 749 (2016), International Journal of Molecular Sciences
- Publication Year :
- 2016
- Publisher :
- MDPI AG, 2016.
-
Abstract
- MicroRNAs (miRNAs) are non-coding RNAs that play essential roles in modulating the gene expression in almost all biological events. In the past decade, the involvement of miRNAs in various cardiovascular disorders has been explored in numerous in vitro and in vivo studies. In this paper, studies focused upon the discovery of miRNAs, their target genes, and functionality are reviewed. The selected miRNAs discussed herein have regulatory effects on target gene expression as demonstrated by miRNA/3′ end untranslated region (3′UTR) interaction assay and/or gain/loss-of-function approaches. The listed miRNA entities are categorized according to the biological relevance of their target genes in relation to three cardiovascular pathologies, namely cardiac hypertrophy, fibrosis, and apoptosis. Furthermore, comparison across 86 studies identified several candidate miRNAs that might be of particular importance in the ontogenesis of cardiovascular diseases as they modulate the expression of clusters of target genes involved in the progression of multiple adverse cardiovascular events. This review illustrates the involvement of miRNAs in diverse biological signaling pathways and provides an overview of current understanding of, and progress of research into, of the roles of miRNAs in cardiovascular health and disease.
- Subjects :
- 0301 basic medicine
Untranslated region
Gene regulatory network
Cardiomegaly
Review
Disease
Biology
Bioinformatics
Catalysis
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
microRNA
Gene expression
Animals
Humans
Gene Regulatory Networks
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Gene
Spectroscopy
Regulation of gene expression
fibrosis
Organic Chemistry
apoptosis
General Medicine
Computer Science Applications
Disease Models, Animal
MicroRNAs
030104 developmental biology
Gene Expression Regulation
lcsh:Biology (General)
lcsh:QD1-999
Cardiovascular Diseases
Signal transduction
hypertrophy
Signal Transduction
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....c0601c375a25be9e6ea65974af70bca8
- Full Text :
- https://doi.org/10.3390/ijms17050749