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Overview of MicroRNAs in Cardiac Hypertrophy, Fibrosis, and Apoptosis

Overview of MicroRNAs in Cardiac Hypertrophy, Fibrosis, and Apoptosis

Authors :
Yei Tsung Chen
Juan Wang
Oi Wah Liew
Arthur Mark Richards
Source :
International Journal of Molecular Sciences, Vol 17, Iss 5, p 749 (2016), International Journal of Molecular Sciences
Publication Year :
2016
Publisher :
MDPI AG, 2016.

Abstract

MicroRNAs (miRNAs) are non-coding RNAs that play essential roles in modulating the gene expression in almost all biological events. In the past decade, the involvement of miRNAs in various cardiovascular disorders has been explored in numerous in vitro and in vivo studies. In this paper, studies focused upon the discovery of miRNAs, their target genes, and functionality are reviewed. The selected miRNAs discussed herein have regulatory effects on target gene expression as demonstrated by miRNA/3′ end untranslated region (3′UTR) interaction assay and/or gain/loss-of-function approaches. The listed miRNA entities are categorized according to the biological relevance of their target genes in relation to three cardiovascular pathologies, namely cardiac hypertrophy, fibrosis, and apoptosis. Furthermore, comparison across 86 studies identified several candidate miRNAs that might be of particular importance in the ontogenesis of cardiovascular diseases as they modulate the expression of clusters of target genes involved in the progression of multiple adverse cardiovascular events. This review illustrates the involvement of miRNAs in diverse biological signaling pathways and provides an overview of current understanding of, and progress of research into, of the roles of miRNAs in cardiovascular health and disease.

Details

ISSN :
14220067
Volume :
17
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences
Accession number :
edsair.doi.dedup.....c0601c375a25be9e6ea65974af70bca8
Full Text :
https://doi.org/10.3390/ijms17050749