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Is bigger always better? The importance of cortical configuration with respect to cognitive ability
- Source :
- Vuoksimaa, E; Panizzon, MS; Chen, CH; Fiecas, M; Eyler, LT; Fennema-Notestine, C; et al.(2016). Is bigger always better? The importance of cortical configuration with respect to cognitive ability. NeuroImage, 129, 356-366. doi: 10.1016/j.neuroimage.2016.01.049. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/86c1h8h3
- Publication Year :
- 2016
- Publisher :
- eScholarship, University of California, 2016.
-
Abstract
- © 2016 Elsevier Inc. General cognitive ability (GCA) has substantial explanatory power for behavioral and health outcomes, but its cortical substrate is still not fully established. GCA is highly polygenic and research to date strongly suggests that its cortical substrate is highly polyregional. We show in map-based and region-of-interest-based analyses of adult twins that a complex cortical configuration underlies GCA. Having relatively greater surface area in evolutionary and developmentally high-expanded prefrontal, lateral temporal, and inferior parietal regions is positively correlated with GCA, whereas relatively greater surface area in low-expanded occipital, medial temporal, and motor cortices is negatively correlated with GCA. Essentially the opposite pattern holds for relative cortical thickness. The phenotypic positive-to-negative gradients in our cortical-GCA association maps were largely driven by a similar pattern of genetic associations. The patterns are consistent with regional cortical stretching whereby relatively greater surface area is related to relatively thinner cortex in high-expanded regions. Thus, the typical "bigger is better" view does not adequately capture cortical-GCA associations. Rather, cognitive ability is influenced by complex configurations of cortical development patterns that are strongly influenced by genetic factors. Optimal cognitive ability appears to be driven both by the absolute size and the polyregional configuration of the entire cortex rather than by small, circumscribed regions.
- Subjects :
- 0301 basic medicine
Male
Cognitive Neuroscience
Image Processing
Neurodevelopment
Intelligence
General cognitive ability
Twins
cortical surface area
Cortical surface area
Biology
Health outcomes
Brain mapping
Medical and Health Sciences
Article
Cortical thickness
03 medical and health sciences
0302 clinical medicine
Computer-Assisted
Cognition
Cortex (anatomy)
medicine
Image Processing, Computer-Assisted
Humans
Twin research
twin research
10. No inequality
Association (psychology)
Cerebral Cortex
Brain Mapping
Neurology & Neurosurgery
neurodevelopment
Psychology and Cognitive Sciences
3112 Neurosciences
cortical thickness
Middle Aged
Twin study
Magnetic Resonance Imaging
3142 Public health care science, environmental and occupational health
general cognitive ability
030104 developmental biology
medicine.anatomical_structure
Neurology
Cerebral cortex
Absolute size
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Vuoksimaa, E; Panizzon, MS; Chen, CH; Fiecas, M; Eyler, LT; Fennema-Notestine, C; et al.(2016). Is bigger always better? The importance of cortical configuration with respect to cognitive ability. NeuroImage, 129, 356-366. doi: 10.1016/j.neuroimage.2016.01.049. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/86c1h8h3
- Accession number :
- edsair.doi.dedup.....c06c4a83e922b4d89970b9c674e3a245