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Heterogeneity and excitability of BRAFV600E-induced tumors is determined by Akt/mTOR-signaling state and Trp53-loss
- Source :
- Neuro-Oncology 24(5), 741-754 (2022). doi:10.1093/neuonc/noab268
- Publication Year :
- 2022
- Publisher :
- Oxford Univ. Press, 2022.
-
Abstract
- Neuro-Oncology 24(5), 741-754 (2022). doi:10.1093/neuonc/noab268<br />Published by Oxford Univ. Press, Oxford
- Subjects :
- Proto-Oncogene Proteins B-raf
Cancer Research
MTOR protein, human
genetics [Proto-Oncogene Proteins B-raf]
metabolism [TOR Serine-Threonine Kinases]
epileptogenicity
Mice
metabolism [Proto-Oncogene Proteins B-raf]
physiology [Signal Transduction]
Animals
Humans
ddc:610
pediatric tumor
Ganglioglioma
dysplastic neuron
Brain Neoplasms
TOR Serine-Threonine Kinases
genetics [TOR Serine-Threonine Kinases]
metabolism [Brain Neoplasms]
genetics [Brain Neoplasms]
Oncology
Mutation
metabolism [Proto-Oncogene Proteins c-akt]
genetics [Ganglioglioma]
genetics [Proto-Oncogene Proteins c-akt]
Neurology (clinical)
neoplastic astroglia
Proto-Oncogene Proteins c-akt
Signal Transduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Neuro-Oncology 24(5), 741-754 (2022). doi:10.1093/neuonc/noab268
- Accession number :
- edsair.doi.dedup.....c084401789e468e8a20d91d828e5463a
- Full Text :
- https://doi.org/10.1093/neuonc/noab268