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Temperature-Dependence of Maturation of Chronotropic and Inotropic Responses to Isoproterenol
- Source :
- Developmental Pharmacology and Therapeutics. 10:133-144
- Publication Year :
- 1987
- Publisher :
- S. Karger AG, 1987.
-
Abstract
- Effects of varying temperature (26, 32, 38 degrees C) on age-related differences in inotropic and chronotropic sensitivities were investigated on electrically stimulated left atria and spontaneously beating right atria isolated from newborn and adult rabbits. Adult tissue had significantly greater sensitivity (low ED50) than newborn tissues to isoproterenol-induced inotropic responses at 26 and 32 degrees C (p less than 0.01), but not at 38 degrees C. The chronotropic sensitivity of adult tissues was significantly greater than the newborn at 26 degrees C (p less than 0.01), but not different at 32 or 38 degrees C. It is concluded that age-related differences in inotropic and chronotropic responses in vitro are more pronounced at low temperatures and tend to disappear at physiological temperatures.
- Subjects :
- Male
Inotrope
Chronotropic
Aging
medicine.medical_specialty
Contractility
Heart Rate
Isoprenaline
Internal medicine
medicine
Animals
Pharmacology (medical)
General Pharmacology, Toxicology and Pharmaceutics
ED50
Lagomorpha
biology
Isoproterenol
Temperature
biology.organism_classification
Myocardial Contraction
Electric Stimulation
Electrophysiology
Endocrinology
Animals, Newborn
Female
Rabbits
medicine.drug
Subjects
Details
- ISSN :
- 25042505 and 03798305
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Developmental Pharmacology and Therapeutics
- Accession number :
- edsair.doi.dedup.....c087b61506d388a12bf988fd87e238f8