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Effect of Platinum-Based Chemotherapy on PD-L1 Expression on Tumor Cells in Non-small Cell Lung Cancer
- Source :
- Cancer Research and Treatment : Official Journal of Korean Cancer Association
- Publication Year :
- 2018
- Publisher :
- Korean Cancer Association, 2018.
-
Abstract
- PURPOSE Programmed death-1 (PD-1)/PD-1 ligand (PD-L1) axis blockades have revolutionized the treatment of advanced non-small cell lung cancer (NSCLC). We assessed the effect of platinum-based chemotherapy on tumor PD-L1 expression and its clinical implications. MATERIALS AND METHODS We used immunohistochemistry to retrospectively evaluate the percentage of tumor cells with membranous PD-L1 staining (tumor proportion score) in paired tumor specimens obtained before and after platinum-based neoadjuvant chemotherapy (NACT) in 86 patients with NSCLC. We analyzed the correlation between the change in PD-L1 tumor proportion score and clinicopathologic characteristics, response to NACT, and survival. RESULTS The PD-L1 tumor proportion score increased in a significant proportion of patients with NSCLC after platinum-based NACT (Wilcoxon signed-rank test, p=0.002). That pattern was consistent across clinically defined subgroups except for patients with partial response to NACT. Tumors from 26 patients (30.2%) were PD-L1‒negative before NACT but PD-L1-positive after NACT, whereas the reverse pattern occurred in six patients (7%) (McNemar's test, p < 0.001). Increase in PD-L1 tumor proportion score was significantly associated with lack of response to NACT (Fisher exact test, p=0.015). There was a tendency, albeit not statistically significant, for patients with an increase in PD-L1 tumor proportion score to have shorter survival. CONCLUSION Tumor PD-L1 expression increased after platinum-based NACT in a significant proportion of patients with NSCLC. Increase in tumor PD-L1 expression may predict poor clinical outcome.
- Subjects :
- 0301 basic medicine
Oncology
PD-L1
Adult
Male
Cancer Research
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
B7-H1 Antigen
Non-small cell lung carcinoma
03 medical and health sciences
symbols.namesake
0302 clinical medicine
McNemar's test
Internal medicine
Carcinoma, Non-Small-Cell Lung
medicine
Humans
Lung cancer
Neoadjuvant therapy
Fisher's exact test
Platinum
Aged
Retrospective Studies
Chemotherapy
biology
business.industry
Middle Aged
medicine.disease
Prognosis
Survival Analysis
Neoadjuvant Therapy
Up-Regulation
Gene Expression Regulation, Neoplastic
030104 developmental biology
Treatment Outcome
Chemotherapy, Adjuvant
030220 oncology & carcinogenesis
biology.protein
symbols
Immunohistochemistry
Original Article
Female
Non small cell
business
Subjects
Details
- Language :
- English
- ISSN :
- 20059256 and 15982998
- Volume :
- 51
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cancer Research and Treatment : Official Journal of Korean Cancer Association
- Accession number :
- edsair.doi.dedup.....c0897959016894cc06ebb96d15beaa0b