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Geographic variation in Alzheimer's disease mortality
- Source :
- PLoS ONE, PLoS ONE, Vol 16, Iss 7, p e0254174 (2021)
- Publication Year :
- 2021
-
Abstract
- Objective Accumulating evidence suggests the possibility that early life exposures may contribute to risk of Alzheimer’s Disease (AD). This paper explores geographic disparities in AD mortality based on both state of residence in older age as well as state of birth measures in order to assess the relative importance of these factors. Methods We use a subset of a large survey, the NIH-AARP Diet and Health Study, of over 150,000 individuals aged 65–70 with 15 years of mortality follow-up, allowing us to study over 1050 cases of AD mortality. We use multi-level logistic regression, where individuals are nested within states of residence and/or states of birth, to assess the contributions of place to AD mortality variation. Results We show that state of birth explains a modest amount of variation in AD mortality, approximately 4%, which is consistent with life course theories that suggest that early life conditions can produce old age health disparities. However, we also show that nearly all of the variation from state of birth is explained by state of residence in old age. Conclusions These results suggest that later life factors are potentially more consequential targets for intervention in reducing AD mortality and provide some evidence against the importance of macro-level environmental exposures at birth as a core determinant of later AD.
- Subjects :
- Male
Epidemiology
Social Sciences
Geographic variation
Disease
Logistic regression
Alzheimer's Disease
Geographical locations
California
0302 clinical medicine
Medical Conditions
Sociology
Risk Factors
Medicine and Health Sciences
Medicine
Public and Occupational Health
030212 general & internal medicine
Multidisciplinary
Disease mortality
Neurodegenerative Diseases
Middle Aged
Early life
Health equity
Socioeconomic Aspects of Health
Neurology
Life course approach
Behavioral and Social Aspects of Health
Research Article
Death Rates
Science
Education
03 medical and health sciences
Population Metrics
Alzheimer Disease
Mental Health and Psychiatry
Humans
Educational Attainment
Aged
Health Care Policy
Population Biology
business.industry
Biology and Life Sciences
United States
Health Care
Medical Risk Factors
North America
Residence
Dementia
People and places
business
030217 neurology & neurosurgery
Demography
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....c0af981200a67a9759cb0c12edf27461