Novel insights into the TRPV3-mediated itch in atopic dermatitis

Authors :: Ciara Larkin
Szabó I
Dermot Walls
Timo Buhl
Jiafu Wang
Song Xiao
Wenke Cheng
Sandra M. O’Neill
Chunxu Shan
Andrea Szegedi
Zsolt Dajnoki
Jianghui Meng
Weiwei Chen
Fan Yuanyuan
Source :: Journal of Allergy and Clinical Immunology. 147:1110-1114.e5
Publication Year :: 2021
Publisher :: Elsevier BV, 2021.
Abstract: This study discovered a novel neuro-epidermal BNP-TRPV3-Serpin E1-mediated pathway in severe atopic dermatitis (AD). Serpin E1 was identified as a new itch-inducer. We propose this pathway represents an important target for the treatment of AD.

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