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Fn14 Participates in Neuropathic Pain Through NF-κB Pathway in Primary Sensory Neurons
- Source :
- Mol Neurobiol
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Fibroblast growth factor-inducible-14 (Fn14), a receptor for tumor necrosis-like weak inducer of apoptosis, is expressed in the neurons of dorsal root ganglion (DRG). Its mRNA is increased in the injured DRG following peripheral nerve injury. Whether this increase contributes to neuropathic pain is unknown. We reported here that peripheral nerve injury caused by spinal nerve ligation (SNL) increased the expression of Fn14 at both protein and mRNA levels in the injured DRG. Blocking this increase attenuated the development of SNL-induced mechanical, thermal, and cold pain hypersensitivities. Conversely, mimicking this increase produced the increases in the levels of phosphorylated extracellular signal-regulated kinase ½ and glial fibrillary acidic protein in ipsilateral dorsal horn and the enhanced responses to mechanical, thermal, and cold stimuli in the absence of SNL. Mechanistically, the increased Fn14 activated the NF-κB pathway through promoting the translocation of p65 into the nucleus of the injured DRG neurons. Our findings suggest that Fn14 may be a potential target for the therapeutic treatment of peripheral neuropathic pain.
- Subjects :
- Male
Pain Threshold
0301 basic medicine
Microinjections
Sensory Receptor Cells
Neuroscience (miscellaneous)
Pharmacology
Article
Mice
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Dorsal root ganglion
Peripheral Nerve Injuries
Ganglia, Spinal
Extracellular
Animals
Medicine
RNA, Messenger
Receptor
Ligation
Cells, Cultured
Glial fibrillary acidic protein
biology
business.industry
Kinase
NF-kappa B
NF-κB
Spinal Nerves
030104 developmental biology
medicine.anatomical_structure
Neurology
chemistry
TWEAK Receptor
Neuropathic pain
Peripheral nerve injury
biology.protein
Neuralgia
business
030217 neurology & neurosurgery
Signal Transduction
Subjects
Details
- ISSN :
- 15591182 and 08937648
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Molecular Neurobiology
- Accession number :
- edsair.doi.dedup.....c0c87d405d4d6720213c3a271166efc2
- Full Text :
- https://doi.org/10.1007/s12035-019-1545-y