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Fn14 Participates in Neuropathic Pain Through NF-κB Pathway in Primary Sensory Neurons

Authors :
Shaogen Wu
Li Na Huang
Yun Zou
Hong Hong Zhang
Yuan Xiang Tao
Qing Xiang Mao
Jin Bao Li
Source :
Mol Neurobiol
Publication Year :
2019
Publisher :
Springer Science and Business Media LLC, 2019.

Abstract

Fibroblast growth factor-inducible-14 (Fn14), a receptor for tumor necrosis-like weak inducer of apoptosis, is expressed in the neurons of dorsal root ganglion (DRG). Its mRNA is increased in the injured DRG following peripheral nerve injury. Whether this increase contributes to neuropathic pain is unknown. We reported here that peripheral nerve injury caused by spinal nerve ligation (SNL) increased the expression of Fn14 at both protein and mRNA levels in the injured DRG. Blocking this increase attenuated the development of SNL-induced mechanical, thermal, and cold pain hypersensitivities. Conversely, mimicking this increase produced the increases in the levels of phosphorylated extracellular signal-regulated kinase ½ and glial fibrillary acidic protein in ipsilateral dorsal horn and the enhanced responses to mechanical, thermal, and cold stimuli in the absence of SNL. Mechanistically, the increased Fn14 activated the NF-κB pathway through promoting the translocation of p65 into the nucleus of the injured DRG neurons. Our findings suggest that Fn14 may be a potential target for the therapeutic treatment of peripheral neuropathic pain.

Details

ISSN :
15591182 and 08937648
Volume :
56
Database :
OpenAIRE
Journal :
Molecular Neurobiology
Accession number :
edsair.doi.dedup.....c0c87d405d4d6720213c3a271166efc2
Full Text :
https://doi.org/10.1007/s12035-019-1545-y