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Potassium channel KIR4.1-specific antibodies in children with acquired demyelinating CNS disease
- Source :
- Neurology. 82:470-473
- Publication Year :
- 2014
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2014.
-
Abstract
- A serum antibody against the inward rectifying potassium channel KIR4.1 (KIR4.1-IgG) was recently discovered, which is found in almost half of adult patients with multiple sclerosis. We investigated the prevalence of KIR4.1-IgG in children with acquired demyelinating disease (ADD) of the CNS. We also compared antibody responses to KIR4.1 and myelin oligodendrocyte glycoproteins (MOGs), another potential autoantigen in childhood ADDs.We measured KIR4.1-IgG by ELISA in children with ADD (n = 47), other neurologic disease (n = 22), and autoimmune disease (n = 22), and in healthy controls (HCs) (n = 18). One hundred six samples were also measured by capture ELISA. Binding of KIR4.1-IgG human subcortical white matter was analyzed by immunofluorescence. Anti-MOG antibodies were measured using a cell-based assay.KIR4.1-IgG titers were significantly higher in children with ADD compared with all control groups by ELISA and capture ELISA (p0.0001, p0.0001). Overall, 27 of 47 patients with ADD (57.45%) but none of the 62 with other neurologic disease or autoimmune disease or the HCs (0%) were KIR4.1-IgG antibody positive by ELISA. Sera containing KIR4.1-IgG stained glial cells in brain tissue sections. No correlation among KIR4.1-IgG, age, or MOG-IgG was observed in the ADD group.Serum antibodies to KIR4.1 are found in the majority of children with ADD but not in children with other diseases or in HCs. These findings suggest that KIR4.1 is an important target of autoantibodies in childhood ADD.
- Subjects :
- Male
Multiple Sclerosis
Adolescent
Enzyme-Linked Immunosorbent Assay
Immunofluorescence
Nerve Fibers, Myelinated
Autoimmune Diseases
White matter
Myelin
Demyelinating disease
medicine
Humans
Potassium Channels, Inwardly Rectifying
Child
Autoantibodies
Autoimmune disease
biology
medicine.diagnostic_test
business.industry
Multiple sclerosis
Autoantibody
Brain
Infant
medicine.disease
medicine.anatomical_structure
Case-Control Studies
Child, Preschool
Immunoglobulin G
Immunology
biology.protein
Female
Myelin-Oligodendrocyte Glycoprotein
Neurology (clinical)
Antibody
business
Neuroglia
Demyelinating Diseases
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....c1154a6f384bb13beb8b2c2351e0c566