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RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway
- Source :
- Clinical and experimental medicine. 21(4)
- Publication Year :
- 2020
-
Abstract
- Hepatocellular carcinoma (HCC) is the most common digestive system cancer. In the current study, we investigated the biological effects of Ras-related protein Rap-2a (RAP2A), a GTPase protein, in HCC tissues and cells. We found that RAP2A was upregulated in HCC tissues and cells. RAP2A knockdown could effectively inhibit the proliferation of HCC cells and weaken its apoptosis resistance. In terms of its action mechanism, RAP2A may be involved in activating the mTOR signaling pathway. Therefore, we believe that RAP2A is abnormally highly expressed in HCC tissues and promotes tumor cell proliferation and apoptosis resistance by activating the mTOR signaling pathway, and it may serve as a potential target for HCC treatment.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Carcinoma, Hepatocellular
Apoptosis
GTPase
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Internal medicine
Cell Line, Tumor
medicine
Humans
neoplasms
PI3K/AKT/mTOR pathway
Cell Proliferation
Gene knockdown
Hematology
Chemistry
TOR Serine-Threonine Kinases
Liver Neoplasms
Cancer
General Medicine
medicine.disease
digestive system diseases
Apoptosis resistance
030104 developmental biology
rap GTP-Binding Proteins
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Cancer research
Subjects
Details
- ISSN :
- 15919528
- Volume :
- 21
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental medicine
- Accession number :
- edsair.doi.dedup.....c11b136da00ca424a27869414f247168