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Isolation and purification of antialgal compounds from the red alga Gracilaria lemaneiformis for activity against common harmful red tide microalgae
- Source :
- Environmental science and pollution research international. 24(5)
- Publication Year :
- 2015
-
Abstract
- Seven antialgal compounds (1–7) were successfully isolated from the red alga Gracilaria lemaneiformis through a combination of silica gel column chromatography and repeated preparative thin-layer chromatography. On the basis of the spectral data, the compounds were identified as gossonorol (1), 7,10-epoxy-ar-bisabol-11-ol (2), glycerol monopalmitate (3), stigmasterol (4), 15-hydroxymethyl-2, 6, 10, 18, 22, 26, 30-heptamethyl-14-methylene-17-hentriacontene (5), 4-hydroxyphenethyl alcohol (6), and margaric acid (7). These seven compounds were isolated from G. lemaneiformis for the first time, while the compounds 4, 6, and 7 were isolated from marine macroalgae for the first time. Furthermore, a quantitative relationship between the inhibition of algal growth and the concentration of each antialgal compound was determined and important parameters for future practical HAB control, e.g., EC50-96h, were also obtained. The results indicated that isolated compounds 1–7 possess selective antialgal activity against the growth of several red tide microalgae (including Amphidinium carterae, Heterosigma akashiwo, Karenia mikimitoi, Phaeocystis globsa, Prorocentrum donghaiense, and Skeletonema costatum). Their antialgal activity against test red tide microalgae has not been previously reported. Furthermore, the EC50-96h of one or more of the compounds towards the tested red microalgae was not only significantly less than 10 μg/mL but also was smaller than that of the characteristic antialgal agent potassium dichromate. The study demonstrates that compounds 1–7 possess significant application potential as antialgal agents against several harmful red tide microalgae.
- Subjects :
- 0106 biological sciences
Health, Toxicology and Mutagenesis
Red tide
Harmful Algal Bloom
ved/biology.organism_classification_rank.species
010501 environmental sciences
01 natural sciences
chemistry.chemical_compound
Column chromatography
Amphidinium carterae
Botany
Microalgae
Environmental Chemistry
Gracilaria
Food science
Potassium dichromate
0105 earth and related environmental sciences
Diatoms
Stigmasterol
biology
ved/biology
010604 marine biology & hydrobiology
Prorocentrum donghaiense
General Medicine
biology.organism_classification
Seaweed
Pollution
Karenia
chemistry
Rhodophyta
Dinoflagellida
Heterosigma akashiwo
Subjects
Details
- ISSN :
- 16147499
- Volume :
- 24
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Environmental science and pollution research international
- Accession number :
- edsair.doi.dedup.....c14b534a9b54df6251a5c2b5b21eb380