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Folic acid supplementation in early second trimester and the risk of preeclampsia
- Source :
- American Journal of Obstetrics and Gynecology. 198:45.e1-45.e7
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Objective The objective of the study was to evaluate the association between folic acid supplementation in early second trimester and the risk of developing preeclampsia. Study Design We carried out a prospective cohort study between October 2002-December 2005. We recruited women who had their prenatal care visit (12-20 weeks’ gestation) at the Ottawa Hospital and Kingston General Hospital. All charts for participants with a diagnosis of preeclampsia were audited and blindly adjudicated by 4 study investigators to validate the diagnosis. Results A total of 2951 pregnant women were included in the final analysis. Supplementation of multivitamins containing folic acid was associated with increased serum folate (on average 10.51 μmol/L), decreased plasma homocysteine (on average 0.39 μmol/L), and reduced risk of preeclampsia (adjusted odds ratio, 0.37; 95% confidence interval, 0.18-0.75). Conclusion Supplementation of multivitamins containing folic acid in the second trimester is associated with reduced risk of preeclampsia.
- Subjects :
- Adult
medicine.medical_specialty
Prenatal care
Risk Assessment
Drug Administration Schedule
Preeclampsia
Cohort Studies
Folic Acid
Pre-Eclampsia
Pregnancy
Reference Values
Confidence Intervals
Odds Ratio
medicine
Humans
Prospective Studies
Risk factor
Prospective cohort study
Probability
Dose-Response Relationship, Drug
Obstetrics
business.industry
Incidence
Pregnancy Outcome
Obstetrics and Gynecology
Prenatal Care
Odds ratio
medicine.disease
Pregnancy Trimester, Second
Dietary Supplements
Gestation
Female
business
Follow-Up Studies
Cohort study
Subjects
Details
- ISSN :
- 00029378
- Volume :
- 198
- Database :
- OpenAIRE
- Journal :
- American Journal of Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....c15ec946c888dd09cd094df4831d0fe4