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Retinol-binding protein 4 in combination with lipids to predict the regression phenomenon of autism spectrum disorders
- Source :
- Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-8 (2021), Lipids in Health and Disease
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background About 20–40 % of autistic people experience a phenomenon of regression. Retinol binding protein 4 (RBP4) plays an important role as an inflammatory neurotrophic adipokine and is a promising mediator of the fat-brain axis. Abnormal fatty acid metabolism and lipid mediators have been reported to be related to the etiological mechanism in autism, and amelioration of impaired lipid metabolism can be recognized as a treatment strategy for autism. The purpose of this study is to explore the relationship between RBP4, lipids, and the autistic regression phenomenon, and to discuss their potentials as biomarkers for the autistic regression phenomenon. Methods A total of 60 autistic individuals (18 with regression phenomenon, 42 without regression phenomenon) (ASD group) and 36 healthy controls were enrolled in this case-control study. The levels of RBP4, total cholesterol (TC), high-density lipoprotein (HDLC), low–density lipoprotein (LDLC), and triglyceride (TG) were measured. Childhood Autism Rating Scale (CARS) is used to assess the severity of autism. Ethical measures were performed in compliance with the current Declaration of Helsinki and written informed consent was obtained from the parents before enrollment of the children and adolescents. Results Compared with control subjects, autistic individuals had lower levels of TC (P = 0.007), RBP4 (P = 0.001), and HDLC (P = 0.027). The levels of RBP4 in ASD group were positively correlated with TG (r = 0.355, P = 0.005), HDLC (r = 0.257, P = 0.047), TG/TC (r = 0.376, P = 0.003) and TG/LDLC (r = 0.363, P = 0.004), and were negatively correlated with CARS (r=-0.296, P = 0.003). Further logistic regression demonstrated that decreased RBP4 concentration was associated with the presentation of the autistic regression phenomenon even after the adjustment of the potential confounding factors. Conclusions Serum RBP4 is associated with the autistic regression phenomenon and the severity of ASD. Further studies are needed to expound whether decreased RBP4 participates in the development of the autistic regression phenomenon.
- Subjects :
- Male
medicine.medical_specialty
RC620-627
Adolescent
Retinol binding protein 4
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Adipokine
autism spectrum disorder
Clinical nutrition
Logistic regression
Triglyceride
Endocrinology
Internal medicine
Humans
Medicine
Child
Nutritional diseases. Deficiency diseases
Triglycerides
Autistic regression
Psychiatric Status Rating Scales
biology
business.industry
Research
Biochemistry (medical)
Confounding
Patient Acuity
Lipid
medicine.disease
Lipids
Lipoproteins, LDL
Cholesterol
Autism spectrum disorder
Case-Control Studies
Child, Preschool
biology.protein
Childhood Autism Rating Scale
Autism
Female
Lipoproteins, HDL
business
Retinol-Binding Proteins, Plasma
Subjects
Details
- Language :
- English
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Lipids in Health and Disease
- Accession number :
- edsair.doi.dedup.....c166ae99f93d36cb40d7896b45cc230f