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Genome-wide signatures of male-mediated migration shaping the Indian gene pool

Authors :
Lluis Quintana-Murci
Varatharajan Santhakumari Arun
Tatiana V. Tatarinova
Fabrício R. Santos
Janet S. Ziegle
GaneshPrasad ArunKumar
Colin Renfrew
Miguel G. Vilar
Matthew E. Kaplan
Adhikarla Syama
R. Spencer Wells
Oleg Balanovsky
Elizabeth Matisoo-Smith
Chris Tyler-Smith
Marta Melé
Daniel E. Platt
Himla Soodyall
Debra Rollo
Amanda C. Owings
Matthew C. Dulik
Valampuri John Kavitha
David F. Soria Hernanz
Nirav Merchant
Bennett Greenspan
Jeff Duty
Begoña Martínez-Cruz
Pandikumar Swamikrishnan
Alan Cooper
Ramasamy Pitchappan
Clio Der Sarkissian
Elena Balanovska
Wolfgang Haak
David Comas
Christina J Adlera
Theodore G. Schurr
Pierre Zalloua
Asif Javed
Andrew Clarke
Jill B. Gaieski
Angela Hobbs
Marc Haber
R. John Mitchell
Ajay K. Royyuru
Pedro Paulo Ribeiro Vieira
Li Jin
Jaume Bertranpetit
Daniela R. Lacerda
Petr Triska
Shi-Lin Li
Laxmi Parida
Source :
Journal of Human Genetics. 60:493-499
Publication Year :
2015
Publisher :
Springer Science and Business Media LLC, 2015.

Abstract

Multiple questions relating to contributions of cultural and demographical factors in the process of human geographical dispersal remain largely unanswered. India, a land of early human settlement and the resulting diversity is a good place to look for some of the answers. In this study, we explored the genetic structure of India using a diverse panel of 78 males genotyped using the GenoChip. Their genome-wide single-nucleotide polymorphism (SNP) diversity was examined in the context of various covariates that influence Indian gene pool. Admixture analysis of genome-wide SNP data showed high proportion of the Southwest Asian component in all of the Indian samples. Hierarchical clustering based on admixture proportions revealed seven distinct clusters correlating to geographical and linguistic affiliations. Convex hull overlay of Y-chromosomal haplogroups on the genome-wide SNP principal component analysis brought out distinct non-overlapping polygons of F*-M89, H*-M69, L1-M27, O2a-M95 and O3a3c1-M117, suggesting a male-mediated migration and expansion of the Indian gene pool. Lack of similar correlation with mitochondrial DNA clades indicated a shared genetic ancestry of females. We suggest that ancient male-mediated migratory events and settlement in various regional niches led to the present day scenario and peopling of India.

Details

ISSN :
1435232X and 14345161
Volume :
60
Database :
OpenAIRE
Journal :
Journal of Human Genetics
Accession number :
edsair.doi.dedup.....c17b668970cf8b9daeccd966d3a4d896