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Role of rhBMP-7, Fibronectin, And Type I Collagen in Dental Implant Osseointegration Process: An Initial Pilot Study on Minipig Animals
- Source :
- Materials, Volume 14, Issue 9, Materials, Vol 14, Iss 2185, p 2185 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Background: The biological factors involved in dental implant osseointegration need to be investigated to improve implant success. Methods: Twenty-four implants were inserted into the tibias of six minipigs. Bone samples were obtained at 7, 14, and 56 days. Biomolecular analyses evaluated mRNA of BMP-4, -7, Transforming Growth Factor-β2, Interleukin-1β, and Osteocalcin in sites treated with rhBMP-7, Type 1 Collagen, or Fibronectin (FN). Inflammation and osteogenesis were evaluated by histological analyses. Results: At 7 and 14 days, BMP-4 and BMP-7 increased in the sites prepared with rhBMP-7 and FN. BMP-7 remained greater at 56 days in rhBMP-7 and FN sites. BPM-4 at 7 and 14 days increased in Type 1 Collagen sites<br />BMP-7 increased from day 14. FN increased the TGF-β2 at all experimental times, whilst the rhBMP-7 only did so up to 7 days. IL-1β increased only in collagen-treated sites from 14 days. Osteocalcin was high in FN-treated sites. Neutrophilic granulocytes characterized the inflammatory infiltrate at 7 days, and mononuclear cells at 14 and 56 days. Conclusions: This initial pilot study, in a novel way, evidenced that Type 1 Collagen induced inflammation and did not stimulate bone production<br />conversely FN or rhBMP-7 showed neo-osteogenetic and anti-inflammatory properties when directly added into implant bone site.
- Subjects :
- Technology
medicine.medical_treatment
Inflammation
Bone morphogenetic protein
Osseointegration
Article
Andrology
03 medical and health sciences
0302 clinical medicine
fibronectin
medicine
bone morphogenetic proteins
type 1 collagen
General Materials Science
Dental implant
030304 developmental biology
0303 health sciences
Microscopy
QC120-168.85
dental implant
biology
business.industry
QH201-278.5
rhBMP-7
030206 dentistry
Engineering (General). Civil engineering (General)
cytokines
TK1-9971
Fibronectin
Descriptive and experimental mechanics
biology.protein
Osteocalcin
dental implant, fibronectin, rhBMP-7, type 1 collagen, cytokines, bone morphogenetic proteins
Implant
Electrical engineering. Electronics. Nuclear engineering
medicine.symptom
TA1-2040
business
Type I collagen
Subjects
Details
- Language :
- English
- ISSN :
- 19961944
- Database :
- OpenAIRE
- Journal :
- Materials
- Accession number :
- edsair.doi.dedup.....c1829c719499b1a881ae14de1272f6f5
- Full Text :
- https://doi.org/10.3390/ma14092185