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A growth hormone antagonist protects mice against streptozotocin induced glomerulosclerosis even in the presence of elevated levels of glucose and glycated hemoglobin
- Source :
- Endocrinology. 137(11)
- Publication Year :
- 1996
-
Abstract
- Transgenic mice expressing growth hormone genes have been shown to have kidney lesions resembling those found in human diabetic patients. However, transgenic mice expressing a growth hormone antagonist gene have normal kidneys. In this study, streptozotocin was used to induce diabetes in growth hormone or growth hormone antagonist transgenic mice and total glycated hemoglobin levels were determined. We found streptozotocin treatment resulted in a significant increase in glycated hemoglobin levels in these animals. Despite comparable levels of glycemia and glycated hemoglobin, severe glomerulosclerosis was found in diabetic and nondiabetic growth hormone transgenic mice; moderate glomerulosclerosis was seen in diabetic nontransgenic mice; and normal glomeruli were seen in diabetic and non-diabetic growth hormone antagonist transgenic mice as well as non-diabetic nontransgenic littermates. These results suggest that growth hormone is playing a role in diabetic nephropathy, and elevated levels of growth hormone can directly affect the kidneys independent of the levels of glucose and glycated hemoglobin.
- Subjects :
- Blood Glucose
medicine.medical_specialty
medicine.medical_treatment
Mice, Transgenic
Diabetes Mellitus, Experimental
Diabetic nephropathy
chemistry.chemical_compound
Mice
Endocrinology
Glomerulonephritis
Internal medicine
Diabetes mellitus
medicine
Animals
Humans
Insulin
Diabetic Nephropathies
Growth Hormone Receptor Antagonist
Glycated Hemoglobin
Kidney
business.industry
Human Growth Hormone
Glomerulosclerosis
Streptozotocin
medicine.disease
medicine.anatomical_structure
chemistry
Growth Hormone
Cattle
Female
Glycated hemoglobin
business
medicine.drug
Subjects
Details
- ISSN :
- 00137227
- Volume :
- 137
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Endocrinology
- Accession number :
- edsair.doi.dedup.....c19d098493b42589a45fbbcb7c016ea1