Back to Search
Start Over
κ-Selenocarrageenan prevents microcystin-LR-induced hepatotoxicity in BALB/c mice
- Source :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 59
- Publication Year :
- 2013
-
Abstract
- Microcystins (MCs) are a family of cyclic heptapeptides that are produced by blooming algae Microcystis. MCs have been implicated in the development of liver cancer, necrosis and even intrahepatic bleeding. Effective prophylactic approaches and complete removal of MCs are urgently needed. Accumulating evidence suggests that microcystin-LR (MC-LR)-induced damage is accompanied by oxidative stress. Supplementation of Se can enhance resistance to oxidative stress. Therefore, in the present study, we investigated the protective effects of κ-Selenocarrageenan (Se-Car), a kind of organic Se compound, in Balb/c mice exposed to MC-LR. Our results proved that Se-Car could significantly ameliorate the hepatic damage induced by MC-LR, including serum markers of liver dysfunction, oxidative damages and histological alterations. Furthermore, Se-Car could significantly alleviate the up-regulation of the molecular targets indicating mitochondrial dysfunction and endoplasmic reticulum stress induced by MC-LR. In conclusion, Se-Car showed clear protection against toxicity induced by MC-LR. Thus, Se-Car could be useful as a new category of anti-MC-LR toxicity reagent.
- Subjects :
- Male
Necrosis
Microcystis
Microcystins
Bacterial Toxins
Microcystin-LR
Cell Cycle Proteins
Mitochondria, Liver
Oxidative phosphorylation
Biology
Pharmacology
Toxicology
medicine.disease_cause
Carrageenan
BALB/c
chemistry.chemical_compound
Mice
Random Allocation
Organoselenium Compounds
medicine
Animals
Hepatic Insufficiency
Eukaryotic Initiation Factors
Adaptor Proteins, Signal Transducing
Mice, Inbred BALB C
Endoplasmic reticulum
General Medicine
biology.organism_classification
medicine.disease
Endoplasmic Reticulum Stress
Phosphoproteins
Survival Analysis
Oxidative Stress
Biochemistry
chemistry
Liver
Toxicity
Marine Toxins
Antitoxins
Lipid Peroxidation
medicine.symptom
Liver cancer
Carrier Proteins
Oxidative stress
Biomarkers
Food Science
Signal Transduction
Subjects
Details
- ISSN :
- 18736351
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Accession number :
- edsair.doi.dedup.....c1b14cf298b6961919e018b1741d0a5a