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Synchrotron microbeam radiation therapy induces hypoxia in intracerebral gliosarcoma but not in the normal brain
- Source :
- Radiotherapy and Oncology, Radiotherapy and Oncology, Elsevier, 2013, 108 (1), pp.143-8. ⟨10.1016/j.radonc.2013.05.013⟩, Radiotherapy and Oncology, Elsevier, 2013, 108 (1), pp.143-148. ⟨10.1016/j.radonc.2013.05.013⟩, Radiotherapy & Oncology, Radiotherapy & Oncology, Elsevier, 2013, 108 (1), pp.143-8. ⟨10.1016/j.radonc.2013.05.013⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; PURPOSE: Synchrotron microbeam radiation therapy (MRT) is an innovative irradiation modality based on spatial fractionation of a high-dose X-ray beam into lattices of microbeams. The increase in lifespan of brain tumor-bearing rats is associated with vascular damage but the physiological consequences of MRT on blood vessels have not been described. In this manuscript, we evaluate the oxygenation changes induced by MRT in an intracerebral 9L gliosarcoma model. METHODS: Tissue responses to MRT (two orthogonal arrays (2×400Gy)) were studied using magnetic resonance-based measurements of local blood oxygen saturation (MR_SO2) and quantitative immunohistology of RECA-1, Type-IV collagen and GLUT-1, marker of hypoxia. RESULTS: In tumors, MR_SO2 decreased by a factor of 2 in tumor between day 8 and day 45 after MRT. This correlated with tumor vascular remodeling, i.e. decrease in vessel density, increases in half-vessel distances (×5) and GLUT-1 immunoreactivity. Conversely, MRT did not change normal brain MR_SO2, although vessel inter-distances increased slightly. CONCLUSION: We provide new evidence for the differential effect of MRT on tumor vasculature, an effect that leads to tumor hypoxia. As hypothesized formerly, the vasculature of the normal brain exposed to MRT remains sufficiently perfused to prevent any hypoxia.
- Subjects :
- Pathology
medicine.medical_specialty
Gliosarcoma
Synchrotron Microbeam Radiation Therapy
Brain Tumors
vessel radiation responses
X-Ray Therapy
Tumor vasculature
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Vessel density
Microbeam radiation therapy
medicine
Animals
Radiology, Nuclear Medicine and imaging
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Glucose Transporter Type 1
medicine.diagnostic_test
Tumor hypoxia
Brain Neoplasms
business.industry
Brain
Magnetic resonance imaging
Hematology
Oxygenation
9l gliosarcoma
medicine.disease
Magnetic Resonance Imaging
Rats
3. Good health
Oxygen
Oncology
Oxygen Saturation
030220 oncology & carcinogenesis
Rat
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Nuclear medicine
business
Synchrotrons
MRI
Subjects
Details
- Language :
- English
- ISSN :
- 01678140
- Database :
- OpenAIRE
- Journal :
- Radiotherapy and Oncology, Radiotherapy and Oncology, Elsevier, 2013, 108 (1), pp.143-8. ⟨10.1016/j.radonc.2013.05.013⟩, Radiotherapy and Oncology, Elsevier, 2013, 108 (1), pp.143-148. ⟨10.1016/j.radonc.2013.05.013⟩, Radiotherapy & Oncology, Radiotherapy & Oncology, Elsevier, 2013, 108 (1), pp.143-8. ⟨10.1016/j.radonc.2013.05.013⟩
- Accession number :
- edsair.doi.dedup.....c1b46f5f990c92984907866b6f57d340
- Full Text :
- https://doi.org/10.1016/j.radonc.2013.05.013⟩