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Means of evaluation and protection from doxorubicin-induced cardiotoxicity and hepatotoxicity in rats
- Source :
- Journal of Cancer Research and Therapeutics, Vol 10, Iss 2, Pp 274-278 (2014)
- Publication Year :
- 2014
- Publisher :
- Wolters Kluwer Medknow Publications, 2014.
-
Abstract
- Objectives: This work is aimed on the study of doxorubicin cardiotoxicity and hepatotoxicity in rats and the evaluation of protective effect of trimetazidine administrated concomitantly with doxorubicin for 3 days. Materials and Methods: Male Wistar rats used were subjected to different types of treatment (3 days); A: Control, B: Doxorubicin treatment and C: Trimetazidine and doxorubicin treatment. After sacrifice, tissular distribution of doxorubicin, cardiac scintigraphy, histological examination of the myocardium, and evaluation of liver function were assessed. Results: Obtained results show that doxorubicin has a high affinity to tissues especially the heart. It causes hepatotoxicity and cardiotoxicity marked by a significant increase of aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) levels and drop of the left ventricular ejection fraction (EF LV ) by scintigraphy. Histological examination showed general alteration of myocardium structure. Concomitant administration of trimetazidine attenuates significantly the cardiotoxicity and hepatotoxity induced by doxorubicin. Conclusion: We have evaluated the protective effect of trimetazidine on an animal model of doxorubicin-induced cardiotoxicity and hepatotoxicity. The evaluation of these effects were assessed by several means; tissular distribution of doxorubicin, histological examination, assessment of liver function, and EF LV by scintigraphy that characterizes the originality of this study.
- Subjects :
- Male
hepatotoxicity
trimetazidine
Trimetazidine
cardiotoxicity
Pharmacology
Scintigraphy
doxorubicin
lcsh:RC254-282
Antioxidants
Ventricular Dysfunction, Left
medicine
polycyclic compounds
Animals
Tissue Distribution
Radiology, Nuclear Medicine and imaging
Doxorubicin
Aspartate Aminotransferases
Rats, Wistar
Cardiotoxicity
Antibiotics, Antineoplastic
Ejection fraction
medicine.diagnostic_test
business.industry
Myocardium
Alanine Transaminase
Stroke Volume
General Medicine
Cardiac scintigraphy
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Liver
Oncology
Concomitant
Liver function
Chemical and Drug Induced Liver Injury
Drug Screening Assays, Antitumor
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 19984138 and 09731482
- Volume :
- 10
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Cancer Research and Therapeutics
- Accession number :
- edsair.doi.dedup.....c1c58d6af7822b1f29937a96279bd486