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Role of specialized pro-resolving lipid mediators and their receptors in virus infection: a promising therapeutic strategy for SARS-CoV-2 cytokine storm
- Source :
- Archives of Pharmacal Research
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Unexpected viral infections outbreaks, significantly affect human health, leading to increased mortality and life disruption. Among them is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which emerged as a deadly pandemic, calling for intense research efforts on its pathogenicity mechanism and development of therapeutic strategies. In the SARS-CoV-2 cytokine storm, systemic inflammation has been associated with severe illness and mortality. Recent studies have demonstrated special pro-resolving lipids mediators (SPMs) lipoxins, resolvins, maresins, and protectins as potential therapeutic options for abnormal viral-triggered inflammation. Pro-resolving lipids mediators have shown great promise for the treatment of Herpes simplex virus, respiratory syncytial virus, human immunodeficiency virus, and hepatitis C virus. Based on this, studies are being conducted on their therapeutic effects in SARS-CoV-2 infection. In this review, we discussed SPMs and reviewed evidence from recent studies on SPMs as therapeutic options for viral infections, including SARS-CoV2. Based on our analysis of the previous study, we argue that SPMs are a potential treatment for SARS-CoV-2 infection and other viral infections. We expect further research on how SPMs modulate viral-triggered inflammation through G-protein-coupled receptors (GPCRs), and chemical stability and druggability of SPMs.
- Subjects :
- 0301 basic medicine
Virus infection
viruses
Hepatitis C virus
Druggability
Chemerin receptor 1
Inflammation
Review
Cytokine storm
Systemic inflammation
medicine.disease_cause
Virus
Receptors, G-Protein-Coupled
03 medical and health sciences
0302 clinical medicine
Pharmacotherapy
Drug Discovery
medicine
Animals
Humans
business.industry
Specialized pro-resolving lipid mediators
Organic Chemistry
COVID-19
medicine.disease
COVID-19 Drug Treatment
Lipoxins
030104 developmental biology
Herpes simplex virus
030220 oncology & carcinogenesis
FPR2/ALX, SARS-CoV2
Immunology
Fatty Acids, Unsaturated
Molecular Medicine
medicine.symptom
Cytokine Release Syndrome
business
Subjects
Details
- Language :
- English
- ISSN :
- 19763786 and 02536269
- Database :
- OpenAIRE
- Journal :
- Archives of Pharmacal Research
- Accession number :
- edsair.doi.dedup.....c20200f0452009730dc795303985baf0
- Full Text :
- https://doi.org/10.1007/s12272-020-01299-y