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Acute and subacute toxicity studies on triptolide and triptolide-loaded polymeric micelles following intravenous administration in rodents
Acute and subacute toxicity studies on triptolide and triptolide-loaded polymeric micelles following intravenous administration in rodents
- Source :
- Food and Chemical Toxicology. 57:371-379
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Except its anti-tumour effects, triptolide (TP) also shows multiple pharmacological side activities, such as immune-suppressive and male anti-fertility. To increase the therapeutic index of TP, a novel polymeric micelle system containing TP (TP-PM) has been developed to treat tumour. Our previous studies have demonstrated the good anti-tumour efficacy of TP-PM. This paper investigated the acute toxicity in mice and subacute toxicity in rats of TP-PM and TP. Results demonstrated that the LD50 for TP-PM and TP administered intravenously were 1.06 mg/kg and 0.83 mg/kg in mice, respectively. In subacute toxicity study, TP-PM and TP were administered intravenously at the dose levels of 0.1 mg/kg and 0.3 mg/kg for 14 d. Compared to the control, there was significant decrease in the serum AST activities, the testis ACP activities, thymus index, testis index, and significant increase in spleen index, and obvious histopathological changes in rats treated with TP, however, the toxicities of TP-PM on liver, kidney, testis and spleen are slighter than TP. Compared to TP, TP-PM significantly increased the ACP activity of the testis and decreased the MDA level in serum. So, the polymeric micelles may be a novel drug delivery carrier of TP for reducing the toxicities of TP.
- Subjects :
- Male
Rodentia
Spleen
Pharmacology
Kidney
Toxicology
Median lethal dose
Lethal Dose 50
Mice
chemistry.chemical_compound
Drug Delivery Systems
Therapeutic index
Testis
Toxicity Tests, Acute
medicine
Animals
Aspartate Aminotransferases
Rats, Wistar
Micelles
Drug Carriers
business.industry
Body Weight
General Medicine
Phenanthrenes
Triptolide
Acute toxicity
Rats
Toxicity Tests, Subacute
medicine.anatomical_structure
Liver
chemistry
Drug delivery
Epoxy Compounds
Administration, Intravenous
Female
Diterpenes
business
Drug carrier
Food Science
Subjects
Details
- ISSN :
- 02786915
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Food and Chemical Toxicology
- Accession number :
- edsair.doi.dedup.....c21474a147008c521c9dde41f521b359
- Full Text :
- https://doi.org/10.1016/j.fct.2013.03.044