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T1andT2mapping for early diagnosis of dilated non-ischaemic cardiomyopathy in middle-aged patients and differentiation from normal physiological adaptation

Authors :
Nikolaos Tzemos
David Carrick
Hiram G. Bezerra
Ify Mordi
Source :
European Heart Journal – Cardiovascular Imaging. 17:797-803
Publication Year :
2015
Publisher :
Oxford University Press (OUP), 2015.

Abstract

Aims The differential diagnosis of patients with early non-ischaemic dilated cardiomyopathy (DCM) and those with physiological adaptation to exercise (‘athlete's heart’) may be difficult as many of the morphological adaptations are shared in the two conditions. Increased physical fitness is becoming more common in later adulthood, a group in whom there may be even more diagnostic difficulty. We hypothesized that tissue characterization using cardiovascular magnetic resonance (CMR) T 1 and T 2 mapping would be able to differentiate between patients with left ventricular (LV) dilatation due to early DCM and exercisers. Methods and results Fifty-eight middle-aged males [21 healthy controls, 21 males with a history of aerobic exercise and LV ejection fraction (LVEF) 45–55%, and 16 patients with DCM and LVEF 45–55%] underwent a CMR protocol including T 1 and T 2 mapping and calculation of extracellular volume (ECV) using a 1.5 T MRI scanner. Native T 1, ECV, and T 2 relaxation times were significantly increased in DCM patients compared with controls (native T 1 1017 ± 42 vs. 952 ± 31 ms, P < 0.001; ECV 31.2 ± 4.1 vs. 26.2 ± 2.9%, P = 0.003; T 2 55.9 ± 4.4 vs. 52.9 ± 3.3 ms, P = 0.05) and exercisers (native T 1 957 ± 32 ms, P < 0.001; ECV 26.3 ± 3.6%, P = 0.004; T 2 52.8 ± 3.2 ms, P = 0.042). Using multivariable logistic regression, native T 1 gave the best differentiation between exercisers and sedentary patients with early DCM (area under the curve 0.91). Conclusion T 1 and T 2 mapping are potentially useful tools for differentiating between athlete's heart and patients with early DCM, and could be used whenever differentiation between these two phenotypes is inconclusive using standard imaging techniques.

Details

ISSN :
20472412 and 20472404
Volume :
17
Database :
OpenAIRE
Journal :
European Heart Journal – Cardiovascular Imaging
Accession number :
edsair.doi.dedup.....c21eae1b2a6410ad712558617b6521a3
Full Text :
https://doi.org/10.1093/ehjci/jev216