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IL-10 mediated regulation of liver inflammation during acute murine cytomegalovirus infection
- Source :
- PLoS ONE, Vol 7, Iss 8, p e42850 (2012), PLoS ONE
- Publication Year :
- 2012
- Publisher :
- Public Library of Science (PLoS), 2012.
-
Abstract
- Various cell types in both lymphoid and non-lymphoid tissues produce the anti-inflammatory cytokine interleukin (IL)-10 during murine cytomegalovirus (MCMV) infection. The functions of IL-10 in the liver during acute infection and the cells that generate this cytokine at this site have not been extensively investigated. In this study, we demonstrate that the production of IL-10 in the liver is elevated in C57BL/6 mice during late acute MCMV infection. Using IL-10 green fluorescence protein (GFP) reporter knock-in mice, designated IL-10-internal ribosomal entry site (IRES)-GFP-enhanced reporter (tiger), NK cells are identified as major IL-10 expressing cells in the liver after infection, along with T cells and other leukocytes. In the absence of IL-10, mice exhibit marked elevations in proinflammatory cytokines and in the numbers of mononuclear cells and lymphocytes infiltrating the liver during this infection. IL-10-deficiency also enhances liver injury without improving viral clearance from this site. Collectively, the results indicate that IL-10-producing cells in the liver provide protection from collateral injury by modulating the inflammatory response associated with MCMV infection.
- Subjects :
- Muromegalovirus
Chemokine
Mouse
medicine.medical_treatment
lcsh:Medicine
NK cells
CD8-Positive T-Lymphocytes
Monocytes
Mice
0302 clinical medicine
Leukocytes
Cytotoxic T cell
lcsh:Science
Immune Response
Liver injury
0303 health sciences
Multidisciplinary
biology
Immune cells
Alanine Transaminase
Animal Models
Viral Load
Interleukin-10
3. Good health
Interleukin 10
Cytokine
Liver
Acute Disease
Cytomegalovirus Infections
Cytokines
Tumor necrosis factor alpha
Chemokines
Inflammation Mediators
medicine.symptom
Research Article
Immunology
T cells
Inflammation
Immunopathology
Microbiology
Proinflammatory cytokine
Immunomodulation
Interferon-gamma
03 medical and health sciences
Model Organisms
Virology
medicine
Animals
Biology
Immunity to Infections
030304 developmental biology
Tumor Necrosis Factor-alpha
lcsh:R
Immunity
Immunoregulation
Immune Defense
medicine.disease
Mice, Inbred C57BL
Immune System
biology.protein
lcsh:Q
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....c21fd0ff36a999c601f87c0f3158fb0c