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Adjuvant chemotherapy, with or without taxanes, in early or operable breast cancer: a meta-analysis of 19 randomized trials with 30698 patients
- Source :
- PLoS ONE, Vol 6, Iss 11, p e26946 (2011), PLoS ONE
- Publication Year :
- 2011
- Publisher :
- Public Library of Science (PLoS), 2011.
-
Abstract
- Background Taxanes have been extensively used as adjuvant chemotherapy for the treatment of early or operable breast cancer, particularly in high risk, node-negative breast cancer. Previous studies, however, have reported inconsistent findings regarding their clinical efficacy and safety. We investigated disease-free survival (DFS), overall survival (OS), and drug-related toxicities of taxanes by a systematic review and meta-analysis. Methodology and Principal Findings We systematically searched PubMed, EMBASE, the Cochrane Center Register of Controlled Trials, proceedings of major meetings, and reference lists of articles for studies conducted between January 1980 and April 2011. Randomized controlled trials (RCTs) comparing chemotherapy with and without taxanes in the treatment of patients with early-stage or operable breast cancer were eligible for inclusion in our analysis. The primary endpoint was DFS. Nineteen RCTs including 30698 patients were identified, including 8426 recurrence events and 3803 deaths. Taxanes administration yielded a 17% reduction of hazard ratio (HR) for DFS (HR = 0.83, 95% CI 0.79–0.88, p
- Subjects :
- Oncology
medicine.medical_specialty
Drugs and Devices
Systematic Reviews
Clinical Research Design
medicine.medical_treatment
Cancer Treatment
lcsh:Medicine
Breast Neoplasms
Biostatistics
Disease-Free Survival
law.invention
Breast cancer
Randomized controlled trial
Adverse Reactions
law
Internal medicine
Breast Cancer
Clinical endpoint
medicine
Humans
lcsh:Science
Survival rate
Randomized Controlled Trials as Topic
Chemotherapy
Multidisciplinary
Taxane
business.industry
Hazard ratio
Statistics
lcsh:R
Obstetrics and Gynecology
Chemotherapy and Drug Treatment
medicine.disease
Survival Rate
Chemotherapy, Adjuvant
Medicine
Women's Health
Female
Taxoids
lcsh:Q
business
Febrile neutropenia
Mathematics
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 6
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....c2234902d42f10e7bbfb828e440951f7