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Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice
- Source :
- Reproductive Toxicology. 26:210-219
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Humans are routinely exposed to bisphenol-A (BPA), an estrogenic compound that leaches from consumer products. Given the sensitivity of the developing organism to hormones, exposure of fetuses and infants is a concern. Here, CD-1 mice were exposed to environmentally relevant doses of BPA during gestation and the lactational period (gestational day 8 through postnatal day 16). At 3, 9 and 12–15 months of age, mammary glands from exposed offspring were examined for structural changes. BPA-exposed females demonstrated altered mammary phenotypes including the appearance of alveolar buds. Additionally, intraductal hyperplasias were observed exclusively in BPA–exposed females. These lesions had the appearance of “beaded” ducts, with epithelial cells present inside the ductal lumen and increased proliferation indexes compared to normal ducts. Similar structures have also been observed following exposure to other estrogens. These results are further evidence that perinatal BPA exposure can alter the morphology of the rodent mammary gland in adulthood.
- Subjects :
- endocrine system
medicine.medical_specialty
Offspring
Mammary gland
Physiology
Biology
Toxicology
Article
Mice
chemistry.chemical_compound
Mammary Glands, Animal
Phenols
Internal medicine
Lactation
medicine
Animals
Benzhydryl Compounds
Cell Proliferation
Hyperplasia
Perinatal Exposure
urogenital system
Xenoestrogen
Endocrinology
medicine.anatomical_structure
Animals, Newborn
chemistry
Endocrine disruptor
Female
Receptors, Progesterone
Breast feeding
hormones, hormone substitutes, and hormone antagonists
Hormone
Subjects
Details
- ISSN :
- 08906238
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Reproductive Toxicology
- Accession number :
- edsair.doi.dedup.....c24a51883dc06fa4c18268e82bc08572