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How to Optimize ECLS Results beyond Ventricular Unloading: From ECMO to CentriMag® eVAD

Authors :
Vincenzo Tarzia
Lorenzo Bagozzi
Matteo Ponzoni
Giacomo Bortolussi
Giulio Folino
Roberto Bianco
Fabio Zanella
Tomaso Bottio
Gino Gerosa
Source :
Journal of Clinical Medicine; Volume 11; Issue 15; Pages: 4605
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

CentriMag® extracorporeal VAD support could represent a more physiological choice than conventional ECMO in primary cardiogenic shock. We therefore evaluated the outcome of patients with primary cardiogenic shock who were supported with CentriMag® extracorporeal VAD implantation versus conventional ECMO. We retrospectively reviewed all extracorporeal life supports implanted for primary cardiogenic shock between January 2009 and December 2018 at our institution. Among 212 patients, 143 cases (67%) were treated exclusively with ECMO (Group 1) and 69 cases (33%) with extracorporeal VAD implantation (Group 2, 48 of whom as conversion of ECMO). ECLS mean duration was 8.37 ± 8.43 days in Group 1 and 14.25 ± 10.84 days in Group 2 (p = 0.001), while the mean rates of the highest predicted flow were 61.21 ± 16.01% and 79.49 ± 18.42% (p = 0.001), respectively. Increasing mechanical support flow was related to in-hospital mortality and overall mortality in Group 1 (HR 11.36, CI 95%: 2.19–44.20), but not in Group 2 (HR 1.48, CI 95%: 0.32–6.80). High-flow ECMO patients had lower survival with respect to high-flow extracorporeal VAD patients (p = 0.027). In the setting of high-flow mechanical circulatory support, CentriMag® extracorporeal VAD optimized patient survival, granting long-term assistance and physiological circulation patterns.

Details

ISSN :
20770383
Volume :
11
Database :
OpenAIRE
Journal :
Journal of Clinical Medicine
Accession number :
edsair.doi.dedup.....c25e9e1aa9e6a88cb609b5380cd3acb7
Full Text :
https://doi.org/10.3390/jcm11154605