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Imaging characterization of benign and malignant pheochromocytoma or paraganglioma: comparison between MIBG uptake and MR signal intensity ratio
- Source :
- Annals of nuclear medicine 26 (2012): 670–675. doi:10.1007/s12149-012-0624-1, info:cnr-pdr/source/autori:Simone Maurea o Alberto Cuocolo o Massimo Imbriaco o Teresa Pellegrino o Mario Fusari o Renato Cuocolo o Raffaele Liuzzi o Marco Salvatore/titolo:Imaging characterization of benign and malignant pheochromocytoma or paraganglioma: comparison between MIBG uptake and MR signal intensity ratio/doi:10.1007%2Fs12149-012-0624-1/rivista:Annals of nuclear medicine/anno:2012/pagina_da:670/pagina_a:675/intervallo_pagine:670–675/volume:26
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- OBJECTIVE: We compared metaiodobenzylguanidine (MIBG) uptake and magnetic resonance (MR) signal intensity ratio in differentiating benign and malignant disease in patients with pheochromocytoma or paraganglioma. METHODS: Eighteen patients (9 men, mean age 37 ± 8 years) with pheochromocytoma or paraganglioma underwent MR imaging and iodine-131 MIBG scintigraphy. MR signal intensity ratio was measured on T1 and T2-weighted images using region of interest analysis and intensity ratio of MIBG uptake was calculated for each tumor lesion on 48 h images. RESULTS: A total of 28 tumor lesions was analyzed of which 12 were benign and 16 malignant. MIBG uptake intensity ratio was significantly higher in malignant lesions compared to benign (5.2 ± 2.4 and 2.9 ± 1.4, respectively, p < 0.01). On the contrary, no significant difference in tumor size and MR signal intensity ratio between malignant and benign tumor lesions was observed. CONCLUSIONS: In patients with pheochromocytoma or paraganglioma, iodine-131 MIBG uptake is able to differentiate between benign and malignant disease, while MR imaging is not useful for this purpose. The higher MIBG uptake observed in malignant lesions could reflect major tumor storage of catecholamines compared to benign lesions.
- Subjects :
- Adult
Male
Malignant Pheochromocytoma
medicine.medical_specialty
endocrine system diseases
Pheochromocytoma
Mibg uptake
Malignant disease
Diagnosis, Differential
Paraganglioma
medicine
Humans
Radiology, Nuclear Medicine and imaging
In patient
Radionuclide Imaging
Retrospective Studies
medicine.diagnostic_test
business.industry
Biological Transport
Magnetic resonance imaging
General Medicine
Middle Aged
equipment and supplies
medicine.disease
Magnetic Resonance Imaging
3-Iodobenzylguanidine
Female
Radiology
Signal intensity
business
Nuclear medicine
human activities
Subjects
Details
- ISSN :
- 18646433 and 09147187
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Annals of Nuclear Medicine
- Accession number :
- edsair.doi.dedup.....c26fd3399772199d956e555cf2b852b2