A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATION

Authors :: Mariana Maier Gaelzer
Itamar Luís Gonçalves
Gabriel Oliveira de Azambuja
Christianne Gazzana Salbego
Vera Lucia Eifler-Lima
CNPq
Source :: Drug Analytical Research; v. 1, n. 1 (2017); p. 56-60, Drug Analytical Research, Vol 1, Iss 1, Pp 56-60 (2017)
Publication Year :: 2017
Publisher :: Universidade Federal do Rio Grande do Sul, 2017.
Abstract: Doxazosin is an important drug used for treating hypertension and prostatic hyperplasia. An enantiomeric mixture (R)/(S) doxazosin mesylate was complete characterized by NMR and additionally FT-IR spectroscopy techniques. Were performed different NMR experiments, such as APT, HSQC, and HMBC in order to confirm the NMR signals assignments. All the hydrogens and the most of carbons atoms were assigned.