Bent Oligonucleotide Duplexes as HMGB1 Inhibitors: a Comparative Study

Authors :: Giovanni N. Roviello
Silvano Fumero
Margherita Valente
Enrico M. Bucci
Maria Moccia
Carlo Pedone
Roberto Sapio
Domenica Musumeci
Musumeci, D
Roviello, Gn
Moccia, M
Pedone, Carlo
Bucci, Em
Sapio, R
Valente, M
Fumero, S.
Musumeci, Domenica
G. N., Roviello
M., Moccia
E. M., Bucci
R., Sapio
M., Valente
S., Fumero
Source :: Nucleosides, nucleotides & nucleic acids 26 (2007): 1447–1450. doi:10.1080/15257770701542330, info:cnr-pdr/source/autori:D. Musumeci; E.M. Bucci; M. Moccia; G.N. Roviello; R. Sapio; M. Valente; C. Pedone; S. Fumero/titolo:Bent oligonucleotide duplexes as HMGB1 inhibitors: a comparative study/doi:10.1080%2F15257770701542330/rivista:Nucleosides, nucleotides & nucleic acids/anno:2007/pagina_da:1447/pagina_a:1450/intervallo_pagine:1447–1450/volume:26
Publication Year :: 2007
Publisher :: Informa UK Limited, 2007.
Abstract: In this work we explore the ability of a chimeric LNA/DNA bent duplex, in which the kink is induced by 2 unpaired adenines in the middle of one strand, to bind HMGB1, a protein involved in many inflammatory processes. The LNA/DNA duplex was compared with the corresponding full DNA and PNA/DNA chimera duplexes from a thermodynamic and spectroscopic point of view.