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X-linked TLR7 gene polymorphisms are associated with diverse immunological conditions but not with discoid lupus erythematosus in Polish patients
- Source :
- Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii
- Publication Year :
- 2018
- Publisher :
- Termedia Publishing House, 2018.
-
Abstract
- Introduction Toll-like receptor 7 (TLR7) is an important molecule involved in the development of autoimmunity and the response to different pathogens. Several polymorphisms within the TLR7 gene were previously found to be associated with systemic lupus erythematosus (SLE). However, none of those studies investigated the TLR7 promoter flanking variants rs1634318 and rs1616583. TLR7 gene diversity has not been analyzed with respect to discoid lupus erythematosus (DLE) development, while its role in the human immunological response to fungal infection is not fully known. Aim To clarify the potential involvement of two novel single-nucleotide polymorphisms (SNPs) located in the TLR7 gene (rs1634318 and rs1616583) in a variety of immune-related conditions, we studied the variability of these loci in patients from a Polish population with SLE and DLE, as well as in immunocompromised patients who were affected by invasive aspergillosis (IA) and those who were not affected. Material and methods Real-time polymerase chain reaction was used to genotype SNPs. Statistically significant differences between case and control groups for both allele and genotype frequencies were assessed using the χ2 test with Yates' correction or two-tailed Fisher's exact test. The results were Bonferroni-corrected for multiple comparisons and odds ratios were calculated. Results Two polymorphisms located in TLR7 might be associated with the development of SLE but not DLE within the Polish population. Moreover, variation of the two investigated SNPs was found to be associated with IA in immunocompromised Polish patients. Conclusions In Polish patients, TLR7 promoter flanking gene polymorphisms might be associated with IA and SLE but not DLE.
- Subjects :
- 0301 basic medicine
Discoid lupus erythematosus
Single-nucleotide polymorphism
Dermatology
medicine.disease_cause
Autoimmunity
polymorphism
03 medical and health sciences
0302 clinical medicine
systemic lupus erythematosus
Genotype
discoid lupus erythematosus
medicine
Immunology and Allergy
aspergillosis
Allele
030203 arthritis & rheumatology
Original Paper
030102 biochemistry & molecular biology
business.industry
allele
virus diseases
TLR7
single-nucleotide polymorphism
medicine.disease
Genotype frequency
Immunology
business
Anti-SSA/Ro autoantibodies
Subjects
Details
- Language :
- English
- ISSN :
- 22990046 and 1642395X
- Volume :
- 35
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii
- Accession number :
- edsair.doi.dedup.....c297e1dbc93c152b8cebc643cc451302