Back to Search
Start Over
Neopterin and Cytokines in Hereditary Dystonia and Parkinson's Disease
- Source :
- Pteridines, Vol 10, Iss 1, Pp 5-13 (1999), Scopus-Elsevier
- Publication Year :
- 1999
- Publisher :
- De Gruyter, 1999.
-
Abstract
- β Both neopterin and biopterin concentrations in cerebrospinal fluid from patients with Parkinson's disease, in which the nigrostriatal dopamine neurons degenerate, were lower than those from age-matched older control subjects. However, the decrease in biopterin was more marked than that in neopterin, resulting in the increase in the neopterin/ biopterin ratio in Parkinson's disease. These results suggests that neopterin in cerebrospinal fluid in Parkinson's disease may partly be derived from immunoactivated glial cells, besides catecholamine or serotonin n eurons including nigrostriatal dopamine neurons. In accordance to this hypothesis, cytokines (TNF-α, IL-1, IL-2 , IL-6, EGF, TGF-α, TGF-β1) were found to be increased in the striatum and/or in cerebrospinal fluid. The increment of cytokines in the brain in Parkinson's disease may be related to the mechanism of neurodegeneration of dopaminergic neurons in Parkinson's disease . In contrast to Parkinson's disease, in hereditary progressive dystonia/ dopa-responsive dystonia, which is a dopamine deficiency caused by mutations in GTP cyclohydrolase I without neuronal cell death (Segawa's disease), neopterin and biopterin in cerebrospinal fluid decreases in parallel owing to the decreased activity in GTP cyclohydrolase I .
- Subjects :
- Parkinson's disease
Crystallography
business.industry
striatum
Clinical Biochemistry
Neopterin
Striatum
medicine.disease
Biochemistry
cytokines
cerebrospinal fluid
nervous system diseases
chemistry.chemical_compound
Cerebrospinal fluid
chemistry
neopterin
immune system diseases
QD901-999
Immunology
parkinson's disease
medicine
Molecular Medicine
Hereditary Dystonia
business
Subjects
Details
- Language :
- English
- ISSN :
- 21954720 and 09334807
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Pteridines
- Accession number :
- edsair.doi.dedup.....c2bb6b42c374f320af90aa8b010bcb12