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Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction
- Source :
- PLoS ONE, Vol 10, Iss 8, p e0135228 (2015), PLoS ONE, PLOS ONE(10): 8
- Publication Year :
- 2015
- Publisher :
- Public Library of Science (PLoS), 2015.
-
Abstract
- Lipid metabolites are indispensable regulators of physiological and pathological processes, including atherosclerosis and coronary artery disease (CAD). However, the complex changes in lipid metabolites and metabolism that occur in patients with these conditions are incompletely understood. We performed lipid profiling to identify alterations in lipid metabolism in patients with angina and myocardial infarction (MI). Global lipid profiling was applied to serum samples from patients with CAD (angina and MI) and age-, sex-, and body mass index-matched healthy subjects using ultra-performance liquid chromatography/quadruple time-of-flight mass spectrometry and multivariate statistical analysis. A multivariate analysis showed a clear separation between the patients with CAD and normal controls. Lysophosphatidylcholine (lysoPC) and lysophosphatidylethanolamine (lysoPE) species containing unsaturated fatty acids and free fatty acids were associated with an increased risk of CAD, whereas species of lysoPC and lyso-alkyl PC containing saturated fatty acids were associated with a decreased risk. Additionally, PC species containing palmitic acid, diacylglycerol, sphingomyelin, and ceramide were associated with an increased risk of MI, whereas PE-plasmalogen and phosphatidylinositol species were associated with a decreased risk. In MI patients, we found strong positive correlation between lipid metabolites related to the sphingolipid pathway, sphingomyelin, and ceramide and acute inflammatory markers (high-sensitivity C-reactive protein). The results of this study demonstrate altered signatures in lipid metabolism in patients with angina or MI. Lipidomic profiling could provide the information to identity the specific lipid metabolites under the presence of disturbed metabolic pathways in patients with CAD.
- Subjects :
- Male
medicine.medical_specialty
Ceramide
Myocardial Infarction
lcsh:Medicine
Fatty Acids, Nonesterified
Angina Pectoris
Coronary artery disease
chemistry.chemical_compound
Internal medicine
medicine
Humans
lcsh:Science
Diacylglycerol kinase
Aged
Multidisciplinary
biology
Cholesterol
C-reactive protein
Fatty Acids
lcsh:R
Lysophosphatidylcholines
Lipid metabolism
Middle Aged
medicine.disease
Lipid Metabolism
Sphingolipid
Endocrinology
C-Reactive Protein
chemistry
Case-Control Studies
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Multivariate Analysis
biology.protein
Fatty Acids, Unsaturated
Metabolome
Female
lipids (amino acids, peptides, and proteins)
lcsh:Q
Lysophospholipids
Sphingomyelin
Biomarkers
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 10
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....c2efd1820debd8531bd42499c058b030