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Cefotiam Treatment in Children: Evidence of Subtherapeutic Levels
- Source :
- Therapeutic drug monitoring. 42(5)
- Publication Year :
- 2020
-
Abstract
- BACKGROUND Cefotiam, a second-generation cephalosporin, is a broad-spectrum antibiotic with good antibacterial action against both gram-negative and gram-positive bacteria. It is used widely in clinical practice, although bacterial drug resistance makes its clinical use problematic. The authors hypothesized that subtherapeutic concentrations of cefotiam leads to bacterial resistance. The present study was conducted to evaluate whether the standard cefotiam dosing regimen resulted in a subtherapeutic concentrations in children. METHOD Data were prospectively collected from pediatric patients with suspected or confirmed community-acquired pneumonia who were receiving cefotiam at the standard dosing regimen (40-80 mg/kg, 2 or 3 times daily). A blood sample was collected after 70%-100% of the dosing interval, and plasma concentrations were determined by high-performance liquid chromatography using an ultraviolet detector. RESULTS The data from 88 patients (age, 3.0 ± 2.8 years; weight, 15.4 ± 8.3 kg) were used for analysis. The average of cefotiam concentrations was 0.06 mcg/mL (range
- Subjects :
- Male
medicine.medical_specialty
Adolescent
medicine.drug_class
Antibiotics
Cephalosporin
Drug resistance
030226 pharmacology & pharmacy
Gastroenterology
Cefotiam
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Pharmacology (medical)
Prospective Studies
Child
Pharmacology
business.industry
Dosing regimen
Infant, Newborn
Infant
Drug Resistance, Microbial
Bacterial Infections
Antimicrobial drug
Anti-Bacterial Agents
Clinical Practice
Child, Preschool
Maximum dose
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 15363694
- Volume :
- 42
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Therapeutic drug monitoring
- Accession number :
- edsair.doi.dedup.....c2ff58395576c0c4bff83b4f6ea496db